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. 2015 Sep 30;7(307):307ra152.
doi: 10.1126/scitranslmed.aab2271.

Early infancy microbial and metabolic alterations affect risk of childhood asthma

Marie-Claire Arrieta  1 , Leah T Stiemsma  2 , Pedro A Dimitriu  3 , Lisa Thorson  4 , Shannon Russell  1 , Sophie Yurist-Doutsch  1 , Boris Kuzeljevic  5 , Matthew J Gold  6 , Heidi M Britton  4 , Diana L Lefebvre  7 , Padmaja Subbarao  8 , Piush Mandhane  9 , Allan Becker  10 , Kelly M McNagny  6 , Malcolm R Sears  7 , Tobias Kollmann  11 ; CHILD Study Investigators; William W Mohn  3 , Stuart E Turvey  12 , B Brett Finlay  13
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Early infancy microbial and metabolic alterations affect risk of childhood asthma (VSports最新版本)

"V体育平台登录" Marie-Claire Arrieta et al. Sci Transl Med. .

"VSports app下载" Abstract

Asthma is the most prevalent pediatric chronic disease and affects more than 300 million people worldwide. Recent evidence in mice has identified a "critical window" early in life where gut microbial changes (dysbiosis) are most influential in experimental asthma. However, current research has yet to establish whether these changes precede or are involved in human asthma. We compared the gut microbiota of 319 subjects enrolled in the Canadian Healthy Infant Longitudinal Development (CHILD) Study, and show that infants at risk of asthma exhibited transient gut microbial dysbiosis during the first 100 days of life. The relative abundance of the bacterial genera Lachnospira, Veillonella, Faecalibacterium, and Rothia was significantly decreased in children at risk of asthma. This reduction in bacterial taxa was accompanied by reduced levels of fecal acetate and dysregulation of enterohepatic metabolites. Inoculation of germ-free mice with these four bacterial taxa ameliorated airway inflammation in their adult progeny, demonstrating a causal role of these bacterial taxa in averting asthma development VSports手机版. These results enhance the potential for future microbe-based diagnostics and therapies, potentially in the form of probiotics, to prevent the development of asthma and other related allergic diseases in children. .

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