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. 2015 Oct;4(10):1589-98.
doi: 10.1002/cam4.496. Epub 2015 Jul 21.

Incidence and persistence of carcinogenic genital human papillomavirus infections in young women with or without Chlamydia trachomatis co-infection

Henrike J Vriend  1   2 , Johannes A Bogaards  1 , Jan E A M van Bergen  3   4 , Antoinette A T P Brink  5 , Ingrid V F van den Broek  1 , Christian J P A Hoebe  5   6 , Audrey J King  1 , Marianne A B van der Sande  1   7 , Petra F G Wolffs  5 , Hester E de Melker  1 ; Medical Microbiological Laboratories and the CSI group
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Incidence and persistence of carcinogenic genital human papillomavirus infections in young women with or without Chlamydia trachomatis co-infection (V体育2025版)

Henrike J Vriend et al. Cancer Med. 2015 Oct.

Abstract

We assessed whether infection with chlamydia increases the incidence of carcinogenic human papillomavirus (HPV) infections and if HPV persistence is affected by chlamydia co-infection. For 1982 women (16-29 years-old) participating in two consecutive rounds of a chlamydia screening implementation trial, swabs were polymerase chain reaction tested to detect chlamydia and 14 carcinogenic HPV genotypes. HPV type-specific incidence and persistence rates were stratified for chlamydia positivity at follow-up. Associations were assessed by multilevel logistic regression analyses with correction for sexual risk factors. HPV type-specific incidence ranged from 1 VSports手机版. 4% to 8. 9% and persistence from 22. 7% to 59. 4% after a median follow-up of 11 months (interquartile range: 11-12). Differences in 1-year HPV persistence rates between chlamydia -infected and noninfected women were less distinct than differences in HPV incidence rates (pooled adjusted odds ratios of 1. 17 [95% CI: 0. 69-1. 96] and 1. 84 [95% CI: 1. 36-2. 47], respectively). The effect of chlamydia co-infection on HPV-infection risk did not significantly differ by HPV genotype. In conclusion, infection with chlamydia increases the risk of infection by carcinogenic HPV types and may enhance persistence of some HPV types. Although these findings could reflect residual confounding through unobserved risk factors, our results do give reason to explore more fully the association between chlamydia and HPV type-specific acquisition and persistence. .

Keywords: Cervical cancer; Chlamydia trachomatis; human papillomavirus; sexually transmitted infection; viral infection V体育安卓版. .

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Figures

Figure 1
Figure 1
Effect of Chlamydia trachomatis (CT) infection at follow-up on type-specific human papillomavirus (HPV) incidence among 1982 Dutch women participating in the Chlamydia Screening Implementation study between 2008–2011. The following data is given for 14 high-risk HPV types, pooled and type-specific, using the imputed data set: number of HPV-incident cases stratified by CT positivity at follow-up; crude and adjusted odds ratio with 95% confidence intervals. The model was adjusted for number of years being sexually active, number of sexual partners in the last 6 months, condom use with the steady and/or casual partner. The denominator of the pooled estimate is the number of individuals negative for at least one of the 14 HPV types at baseline, the numerator is the number of individuals with at least one incident infection. For the type-specific estimates, the denominator is the number of individuals negative for the specific HPV type at baseline, the numerator is the number of individuals with an incident infection for the specific HPV type.
Figure 2
Figure 2
Effect of Chlamydia trachomatis (CT) infection at follow-up on type-specific human papillomavirus (HPV) persistence among 1982 Dutch women participating in the Chlamydia Screening Implementation study between 2008–2011. The following data is given for 14 high-risk HPV types, pooled and type-specific, using the imputed data set: number of HPV-persistent cases stratified by CT positivity at follow-up; crude and adjusted odds ratio with 95% confidence intervals. The model was adjusted for number of years being sexually active, number of sexual partners in the last 6 months, condom use with the steady and/or casual partner. The denominator of the pooled estimate is the number of individuals positive for at least one of the 14 HPV types at baseline, the numerator is the number of individuals with at least one persistent infection. For the type-specific estimates the denominator is the number of individuals positive for the specific HPV type at baseline, the numerator is the number of individuals with a persistent infection for the specific HPV type.
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