<u date-time="BdwLTu"></u><sub date-time="W06Y6"></sub><sub date-time="m4m4iit"><small dropzone="bOoHaO"></small></sub>
Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or . mil VSports app下载. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure V体育官网. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. .

. 2015 Oct;21(10):1721-31.
doi: 10.1016/j.bbmt.2015.06.019. Epub 2015 Jul 4.

Stromal-Derived Factor-1α and Interleukin-7 Treatment Improves Homeostatic Proliferation of Naïve CD4(+) T Cells after Allogeneic Stem Cell Transplantation (VSports注册入口)

Simon-David Gauthier  1 , Dominique Leboeuf  2 , Renaud Manuguerra-Gagné  2 , Louis Gaboury  3 , Martin Guimond  4
Affiliations
Free article

Stromal-Derived Factor-1α and Interleukin-7 Treatment Improves Homeostatic Proliferation of Naïve CD4(+) T Cells after Allogeneic Stem Cell Transplantation

Simon-David Gauthier et al. Biol Blood Marrow Transplant. 2015 Oct.
Free article

Abstract

Graft-versus-host disease (GVHD) impairs immune reconstitution after allogeneic stem cell transplantation (allo-SCT) and effective therapies aimed at restoring T cell counts in GVHD patients have yet to be developed. During GVHD, CD4(+) T cell reconstitution is particularly affected and current models hold that GVHD insult to the peripheral lymphoid niche is responsible for this effect. Here, we show that naïve CD4(+) T cell homeostatic proliferation (HP) is lost during GVHD because of low systemic IL-7 and impaired dendritic cell (DC) regeneration. We assessed factors involved in DC differentiation and found that although fms-like tyrosine kinase 3 ligand (Flt3-L) levels were normal, stromal-derived factor-1α (SDF-1α) was diminished in the blood of GVHD mice VSports手机版. Unlike Flt3-L treatment, the administration of SDF-1α specifically increased CD8α(+) DC numbers and did not worsen GVHD. Importantly, CD4(+) T cell HP was enhanced only when IL-7 and SDF-1α or Flt3L were coadministered, confirming the crucial role of DCs and IL-7 in restoring CD4(+) T cell regeneration during GVHD. Altogether, our results indicate that CD8α(+) DCs are part of the peripheral niche that controls CD4(+) T cell HP and that their depletion, combined with low systemic IL-7, explains how GVHD constrains naïve CD4(+) T cell reconstitution after allo-SCT. .

Keywords: CD4(+) T lymphocytes; Dendritic cells; Flt3-ligand; Graft-versus-host disease; Homeostatic proliferation; Interleukin-7; Stromal-derived factor-1α. V体育安卓版.

PubMed Disclaimer

Publication types

VSports在线直播 - MeSH terms

Substances

LinkOut - more resources