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. 2015 Mar 15;8(3):3707-15.
eCollection 2015.

V体育平台登录 - Expression of lncRNA-CCAT1, E-cadherin and N-cadherin in colorectal cancer and its clinical significance

Zhenyu Ye  1 , Ming Zhou  1 , Bin Tian  1 , Bin Wu  1 , Juncheng Li  1
Affiliations

"VSports最新版本" Expression of lncRNA-CCAT1, E-cadherin and N-cadherin in colorectal cancer and its clinical significance

Zhenyu Ye et al. Int J Clin Exp Med. .

Abstract (V体育平台登录)

Objective: To explore the expression and clinical significance of IncRNA-CCAT and EMT related molecule E-cadherin and N-cadherin in colorectal cancer VSports手机版. .

Methods: The expression of IncRNA-CCAT1, E-cadherin and N-cadherin in 37 colorectal cancer tissue and para-carcinoma tissue was detected using qRT-PCR method, and the correlation of expression level with clinical and pathological features was studied. V体育安卓版.

Results: The expression of IncRNA-CCAT1 in tumor tissue was significantly higher than that in normal para-carcinoma tissue (P < 0. 001), and the expression level of CCAT1was significantly correlated with local infiltration depth (P < 0. 001), tumor staging (P < 0. 001), vascular invasion (P < 0. 001) and CA19-9 level (P < 0. 001); but not related with age, gender, location of tumor, tumor differentiation level, size of primary lesion and level of CEA (P > 0. 05). The expression of E-cadherin in tumor tissues was significantly lower than in normal para-carcinoma tissues (P < 0. 001), and the expression of N-cadherin was significantly higher than that in normal para-carcinoma tissues. The decrease in expression of E-cadherin and increase in expression of N-cadherin were significantly correlated with local infiltration depth (P < 0 V体育ios版. 001), tumor staging (P < 0. 001), vascular invasion (P < 0. 001), tumor differentiation level (P < 0. 001) and CA19-9 level (P < 0. 001), however not related with age, gender, tumor location, size of primary lesion and CEA level (P > 0. 05). .

Conclusion: CCAT1 plays an important role in the genesis, development, invasion and metastasis; it mediates the EMT process of colorectal cancer; and it's expected to be a new marker and treatment target in colorectal diagnosis and treatment. VSports最新版本.

Keywords: CCAT1; E-cadherin; EMT; N-cadherin; colorectal cancer; lncRNA. V体育平台登录.

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Figures

Figure 1
Figure 1
The total RNA quality by agarose gel electrophoresis.
Figure 2
Figure 2
The comparison between cancer tissue and para-cancer tissue expression in CCAT1.
Figure 3
Figure 3
The comparison between cancer tissue and para-cancer tissue expression in E-cadherin.
Figure 4
Figure 4
The comparison between cancer tissue and para-cancer tissue expression in N-cadherin.
See this image and copyright information in PMC

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