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. 2015 Mar;36(3):121-3.
doi: 10.1016/j.it.2015.01.001.

V体育平台登录 - Our interface with the built environment: immunity and the indoor microbiota

Simon Lax  1 , Cathryn R Nagler  2 , Jack A Gilbert  3
Affiliations

"V体育官网入口" Our interface with the built environment: immunity and the indoor microbiota

Simon Lax et al. Trends Immunol. 2015 Mar.

Abstract

The rise of urbanization and an increasingly indoor lifestyle has affected human interactions with our microbiota in unprecedented ways. We discuss how this lifestyle may influence immune development and function, and argue that it is time that we examined ways to manipulate the indoor environment to increase our exposure to a wider phylogeny of microorganisms VSports手机版. An important step is to continue to engage citizen scientists in the efforts to characterize our interactions with the diverse microbial environments that we inhabit. .

Keywords: built environment; microbiome. V体育安卓版.

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Figures

Figure I
Figure I
Citizen scientists for the Home Microbiome Project (http://www.homemicrobiome.com) were reached by advertising on social media platforms (e.g., @homemicrobiome and https://www.facebook.com/HomeMicrobiome) and programs such as SciStarter (http://scistarter.com/project/562-Home%20Microbiome%20Study). Interested parties contacted us by email or through the media and were interviewed on the phone or via email to determine their reasons and suitability for inclusion. Accepted participants were consented through an institutional review board (IRB) and then sent sampling kits (containing a description of what they should do and sterile synthetic material swabs moistened with saline solution), a small freezer for onsite storage, and a brief questionnaire. Samples were returned to our laboratory at Argonne National Labs (http://www.anl.gov) and processed by extracting the DNA and amplifying the 16S rRNA gene by PCR. These amplicons and the raw DNA were then sequenced to produce 16S rRNA and shotgun metagenomic sequence data. These data were analyzed and used for publication, while simultaneously being communicated directly to the participants. Participants were also contacted following publication to allow them to fully understand how their data were used, and what the final published results showed in terms of advancing science. While the raw sequence data were published on data archive sites (e.g., The NCBI Short Read Archive; http://www.ncbi.nlm.nih.gov/sra) the results were published through the scientific literature, traditional media (e.g., http://phenomena.nationalgeographic.com/2014/08/28/we-constantly-imprint-our-homes-with-our-microbes/), and Facebook (e.g., https://www.facebook.com/HomeMicrobiome). Photos courtesy of Katharine Gilbert.
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References

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