Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site VSports app下载. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. V体育官网.

Review
. 2015 Sep;67(1):101-7.
doi: 10.1016/j.molimm.2015.02.027. Epub 2015 Mar 6.

VSports app下载 - The role of complement factor C3 in lipid metabolism

Andreea Barbu  1 , Osama A Hamad  2 , Lars Lind  3 , Kristina N Ekdahl  2 , Bo Nilsson  2
Affiliations
Review

The role of complement factor C3 in lipid metabolism (V体育安卓版)

Andreea Barbu (V体育2025版) et al. Mol Immunol. 2015 Sep.

Abstract

Abundant reports have shown that there is a strong relationship between C3 and C3a-desArg levels, adipose tissue, and risk factors for cardiovascular disease, metabolic syndrome and diabetes. The data indicate that complement components, particularly C3, are involved in lipid metabolism. The C3 fragment, C3a-desArg, functions as a hormone that has insulin-like effects and facilitates triglyceride metabolism VSports手机版. Adipose tissue produces and regulates the levels of complement components, which promotes generation of inflammatory initiators such as the anaphylatoxins C3a and C5a. The anaphylatoxins trigger a cyto/chemokine response in proportion to the amount of adipose tissue present, and induce inflammation and mediate metabolic effects such as insulin resistance. These observations support the concept that complement is an important participant in lipid metabolism and in obesity, contributing to the metabolic syndrome and to the low-grade inflammation associated with obesity. .

Keywords: Apolipoproteins; C3; C3a-desArg; Metabolic syndrome (MetS); Obesity V体育安卓版. .

PubMed Disclaimer

Publication types

MeSH terms