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. 2015 Mar;22(3):256-64.

doi: 10.1038/nsmb.2959. Epub 2015 Feb 9.

Exon-intron circular RNAs regulate transcription in the nucleus

Zhaoyong Li¹, Chuan Huang², Chun Bao³, Liang Chen², Mei Lin², Xiaolin Wang², Guolin Zhong², Bin Yu², Wanchen Hu², Limin Dai², Pengfei Zhu², Zhaoxia Chang², Qingfa Wu², Yi Zhao⁴, Ya Jia⁵, Ping Xu⁶, Huijie Liu², Ge Shan¹

Affiliations

Affiliations

¹ 1] School of Life Sciences, University of Science and Technology of China, Hefei, China. [2] Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei, China.
² School of Life Sciences, University of Science and Technology of China, Hefei, China.
³ 1] School of Life Sciences, University of Science and Technology of China, Hefei, China. [2] Department of Physics, Central China Normal University, Wuhan, China. [3] Institute of Biophysics, Central China Normal University, Wuhan, China.
⁴ Institute of Computing Technology, Chinese Academy of Sciences, Beijing, China.
⁵ 1] Department of Physics, Central China Normal University, Wuhan, China. [2] Institute of Biophysics, Central China Normal University, Wuhan, China.
⁶ National Center for Protein Sciences, Beijing, China.

PMID: 25664725
DOI: 10.1038/nsmb.2959

Exon-intron circular RNAs regulate transcription in the nucleus

Zhaoyong Li et al. Nat Struct Mol Biol. 2015 Mar.

. 2015 Mar;22(3):256-64.

doi: 10.1038/nsmb.2959. Epub 2015 Feb 9.

Authors

Zhaoyong Li¹, Chuan Huang², Chun Bao³, Liang Chen², Mei Lin², Xiaolin Wang², Guolin Zhong², Bin Yu², Wanchen Hu², Limin Dai², Pengfei Zhu², Zhaoxia Chang², Qingfa Wu², Yi Zhao⁴, Ya Jia⁵, Ping Xu⁶, Huijie Liu², Ge Shan¹

Affiliations (VSports注册入口)

¹ 1] School of Life Sciences, University of Science and Technology of China, Hefei, China. [2] Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei, China.
² School of Life Sciences, University of Science and Technology of China, Hefei, China.
³ 1] School of Life Sciences, University of Science and Technology of China, Hefei, China. [2] Department of Physics, Central China Normal University, Wuhan, China. [3] Institute of Biophysics, Central China Normal University, Wuhan, China.
⁴ Institute of Computing Technology, Chinese Academy of Sciences, Beijing, China.
⁵ 1] Department of Physics, Central China Normal University, Wuhan, China. [2] Institute of Biophysics, Central China Normal University, Wuhan, China.
⁶ National Center for Protein Sciences, Beijing, China.

PMID: 25664725
DOI: 10.1038/nsmb.2959

Erratum in

Corrigendum: Exon-intron circular RNAs regulate transcription in the nucleus.
Li Z, Huang C, Bao C, Chen L, Lin M, Wang X, Zhong G, Yu B, Hu W, Dai L, Zhu P, Chang Z, Wu Q, Zhao Y, Jia Y, Xu P, Liu H, Shan G. Li Z, et al. Nat Struct Mol Biol. 2017 Feb 6;24(2):194. doi: 10.1038/nsmb0217-194a. Nat Struct Mol Biol. 2017. PMID: 28170000 No abstract available.

Abstract

Noncoding RNAs (ncRNAs) have numerous roles in development and disease, and one of the prominent roles is to regulate gene expression VSports手机版. A vast number of circular RNAs (circRNAs) have been identified, and some have been shown to function as microRNA sponges in animal cells. Here, we report a class of circRNAs associated with RNA polymerase II in human cells. In these circRNAs, exons are circularized with introns 'retained' between exons; we term them exon-intron circRNAs or EIciRNAs. EIciRNAs predominantly localize in the nucleus, interact with U1 snRNP and promote transcription of their parental genes. Our findings reveal a new role for circRNAs in regulating gene expression in the nucleus, in which EIciRNAs enhance the expression of their parental genes in cis, and highlight a regulatory strategy for transcriptional control via specific RNA-RNA interaction between U1 snRNA and EIciRNAs. .

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Comment in

Not just a sponge: new functions of circular RNAs discovered.
Wang Z. Wang Z. Sci China Life Sci. 2015 Apr;58(4):407-8. doi: 10.1007/s11427-015-4826-3. Epub 2015 Feb 14. Sci China Life Sci. 2015. PMID: 25680857 No abstract available.
Non-coding RNA: Circular RNAs promote transcription.
Zlotorynski E. Zlotorynski E. Nat Rev Mol Cell Biol. 2015 Apr;16(4):206. doi: 10.1038/nrm3967. Epub 2015 Feb 25. Nat Rev Mol Cell Biol. 2015. PMID: 25714680 No abstract available.

VSports app下载 - References

1. Cell. 2013 Jul 3;154(1):26-46 - PubMed (VSports最新版本)
1. Mol Cell. 2013 Sep 26;51(6):792-806 - PubMed
1. Cell. 1991 Feb 8;64(3):607-13 - VSports注册入口 - PubMed
1. Nat Rev Mol Cell Biol. 2006 Aug;7(8):612-6 - PubMed
1. Mol Cell. 2008 Feb 1;29(2):271-8 - PubMed

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