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. 2014 Dec 14:12:354.
doi: 10.1186/s12967-014-0354-3.

VSports最新版本 - Site-specific metabolic phenotypes in metastatic breast cancer

Hye Min Kim  1 , Woo Hee Jung  2 , Ja Seung Koo  3
Affiliations

Site-specific metabolic phenotypes in metastatic breast cancer

Hye Min Kim et al. J Transl Med. .

Abstract

Background: The purpose of this study was to examine the expression of metabolism-related proteins according to metastatic site in metastatic breast cancer and to assess the implication of site-specific differential expression VSports手机版. .

Methods: A tissue microarray containing 162 cases of metastatic breast cancer (52 lung metastasis, 47 bone metastasis, 39 brain metastasis, and 24 liver metastasis) was constructed. It was subject to immunohistochemical staining of the following proteins: Glycolysis-related: Glut-1, hexolinase II, carbonic anhydrase (CA) IX, and monocarboxylate transporter (MCT) 4; glutaminolysis-related: glutaminase (GLS) 1, glutamate dehydrogenase (GDH), and amino acid transporter (ASCT) 2; mitochondrial metabolism-related: ATP synthase, succinate dehydrogenase (SDH)A, and SDHB; and serine/glycine metabolism related: phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase (PSAT), phosphoserine phosphatase (PSPH), glycine decarboxylase (GLDC), and serine hydroxymethyltransferase (SHMT). V体育安卓版.

Results: The expression levels of glycolysis-related-proteins (Glut-1, hexokinase II, CAIX, and MCT4) differed according to metastatic site, with higher expression seen in the brain and lower expression in the bone and liver (p < 0. 001, 0. 001, 0 V体育ios版. 009, and <0. 001, respectively). Differences in metabolic phenotype were analyzed according to metastasis site. Glycolysis type was most frequently encountered in the brain and lung (p < 0. 001). In univariate analysis, the factors associated with shorter overall survival were CAIX positivity (p = 0. 044), PSPH positivity (p = 0. 045), and SHMT1 positivity (p = 0. 002), as well as serine/glycine type (p = 0. 041). .

Conclusions: Differences in metabolic features according to metastatic site were seen in metastatic breast cancer, with the glycolysis phenotype found predominantly in the brain and lung and the non-glycolysis phenotype in the bone and liver VSports最新版本. .

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Figures

Figure 1
Figure 1
Differential expression of metabolism-related proteins in breast cancer metastasis according to metastatic site. The expression of glycolysis-related proteins (Glut-1, hexokinase II, CAIX, and MCT4) was higher in the brain and lower in the bone and liver. The stromal expression levels of MCT4, PHGDH, and SHMT1 were higher in bone metastasis than other sites.
Figure 2
Figure 2
Expression of Glut-1 and MCT4 in primary and metastatic breast cancer. There was no expression of Glut-1 and MCT4 in primary breast cancer, while the expression of Glut-1 and MCT4 increased in lung metastasis.
Figure 3
Figure 3
Correlation between pathologic factors and expression of metabolism-related proteins.
Figure 4
Figure 4
Association between expression level of metabolism-related proteins and patient prognosis in metastatic breast cancer.
Figure 5
Figure 5
Association between expression level of metabolism-related proteins and patient prognosis in metastatic breast cancer according to the metastatic sites.
See this image and copyright information in PMC

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