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. 2014 Sep;7(9):e11945.
doi: 10.5812/jjm.11945. Epub 2014 Sep 1.

Detection of human papillomavirus-16 e6-oncoprotein in epithelial ovarian tumors samples of iraqi patients (V体育安卓版)

Fahem Mohsin Mahmood  1 , Haider Sabah Kadhim  1 , Liqaa Riadh Mousa Al Khuzaee  2
Affiliations

"V体育安卓版" Detection of human papillomavirus-16 e6-oncoprotein in epithelial ovarian tumors samples of iraqi patients

"V体育官网" Fahem Mohsin Mahmood et al. Jundishapur J Microbiol. 2014 Sep.

Abstract

Background: Human papillomavirus (HPV) is the causal factor for cervical cancer VSports手机版. However, the role of HPV infection in ovarian cancer is unclear. .

Objectives: This study aimed to determine the presence of human papillomavirus-16 (HPV-16) in ovarian tumor tissues. V体育安卓版.

Patients and methods: This was a retrospective study, which included 61 Archived human ovarian tumor tissues embedded in paraffin blocks. The ovarian tumor tissues were divided into four groups. The first group was the malignant ovarian epithelial tumor group; it included 31 cases with invasive surface epithelial ovarian tumors. The second group was the borderline epithelial ovarian tumor group: it included four cases with borderline intermediate malignancy. The third group was the benign epithelial ovarian tumors group: it included 18 cases with benign epithelial ovarian tumors. The fourth group had functional ovarian cystic lesions: it included eight cases with non-neoplastic functional ovarian cysts. Sections were made from each of the paraffin embedded blocks and examined using immunohistochemistry to detect HPV 16-E6-oncoprotein in ovarian tumor tissues V体育ios版. .

Results: Out of the eight cases with functional cysts only one case (12. 5%) expressed HPV. No HPV expression was seen in cases with benign and borderline tumors. Out of the 31 cases with one malignant surface epithelial ovarian tumor only three (9 VSports最新版本. 67%) cases expressed HPV. There was no significant statistical difference in HPV expression among neoplastic and non-neoplastic ovarian tumors included in the present study (P= 0. 476). .

Conclusions: HPV type 16 was detected in only 9. 67% of malignant epithelial tumors. It appears that HPV infection plays a relatively minor role in the pathogenesis of ovarian carcinomas V体育平台登录. .

Keywords: Human Papillomavirus-16; Immunohistochemistry; Tumor. VSports注册入口.

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Figures

Figure 1.
Figure 1.. Functional Ovarian Cyst Cases
See this image and copyright information in PMC

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