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. 2014 Oct 23;159(3):514-29.
doi: 10.1016/j.cell.2014.09.048. Epub 2014 Oct 16.

Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis

Christoph A Thaiss  1 , David Zeevi  2 , Maayan Levy  1 , Gili Zilberman-Schapira  1 , Jotham Suez  1 , Anouk C Tengeler  1 , Lior Abramson  1 , Meirav N Katz  3 , Tal Korem  2 , Niv Zmora  4 , Yael Kuperman  5 , Inbal Biton  5 , Shlomit Gilad  6 , Alon Harmelin  5 , Hagit Shapiro  1 , Zamir Halpern  7 , Eran Segal  2 , Eran Elinav  8
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Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis

Christoph A Thaiss (V体育官网入口) et al. Cell. .
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V体育安卓版 - Abstract

All domains of life feature diverse molecular clock machineries that synchronize physiological processes to diurnal environmental fluctuations. However, no mechanisms are known to cross-regulate prokaryotic and eukaryotic circadian rhythms in multikingdom ecosystems. Here, we show that the intestinal microbiota, in both mice and humans, exhibits diurnal oscillations that are influenced by feeding rhythms, leading to time-specific compositional and functional profiles over the course of a day. Ablation of host molecular clock components or induction of jet lag leads to aberrant microbiota diurnal fluctuations and dysbiosis, driven by impaired feeding rhythmicity. Consequently, jet-lag-induced dysbiosis in both mice and humans promotes glucose intolerance and obesity that are transferrable to germ-free mice upon fecal transplantation VSports手机版. Together, these findings provide evidence of coordinated metaorganism diurnal rhythmicity and offer a microbiome-dependent mechanism for common metabolic disturbances in humans with aberrant circadian rhythms, such as those documented in shift workers and frequent flyers. .

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