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Review
. 2014 Nov;32(9):470-95.
doi: 10.3109/07357907.2014.958231. Epub 2014 Sep 25.

"VSports在线直播" The cancer stem cell hypothesis: a guide to potential molecular targets

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Review

The cancer stem cell hypothesis: a guide to potential molecular targets

Alessandro Allegra et al. Cancer Invest. 2014 Nov.

Abstract

Common cancer theories hold that tumor is an uncontrolled somatic cell proliferation caused by the progressive addition of random mutations in critical genes that control cell growth. Nevertheless, various contradictions related to the mutation theory have been reported previously VSports手机版. These events may be elucidated by the persistence of residual tumor cells, called Cancer Stem Cells (CSCs) responsible for tumorigenesis, tumor maintenance, tumor spread, and tumor relapse. Herein, we summarize the current understanding of CSCs, with a focus on the possibility to identify specific markers of CSCs, and discuss the clinical application of targeting CSCs for cancer treatment. .

Keywords: Cancer stem cell; Chemoresistance; Hematologic disease; Leukemia; Marker; Oncology; Relapse V体育安卓版. .

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