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Observational Study
. 2014 Dec 2;130(23):2031-9.
doi: 10.1161/CIRCULATIONAHA.113.006824. Epub 2014 Sep 19.

"V体育官网" Assessment of atherosclerosis in chronic granulomatous disease

Christopher T Sibley  1 , Tyra Estwick  1 , Anna Zavodni  1 , Chiung-Yu Huang  1 , Alan C Kwan  1 , Benjamin P Soule  1 , Debra A Long Priel  1 , Alan T Remaley  1 , Amanda K Rudman Spergel  1 , Evrim B Turkbey  1 , Douglas B Kuhns  1 , Steven M Holland  1 , Harry L Malech  1 , Kol A Zarember  1 , David A Bluemke  1 , John I Gallin  2
Affiliations
Observational Study

Assessment of atherosclerosis in chronic granulomatous disease

Christopher T Sibley et al. Circulation. .

Abstract

Background: Patients with chronic granulomatous disease (CGD) experience immunodeficiency because of defects in the phagocyte NADPH oxidase and the concomitant reduction in reactive oxygen intermediates VSports手机版. This may result in a reduction in atherosclerotic injury. .

Methods and results: We prospectively assessed the prevalence of cardiovascular risk factors, biomarkers of inflammation and neutrophil activation, and the presence of magnetic resonance imaging and computed tomography quantified subclinical atherosclerosis in the carotid and coronary arteries of 41 patients with CGD and 25 healthy controls in the same age range V体育安卓版. Univariable and multivariable associations among risk factors, inflammatory markers, and atherosclerosis burden were assessed. Patients with CGD had significant elevations in traditional risk factors and inflammatory markers compared with control subjects, including hypertension, high-sensitivity C-reactive protein, oxidized low-density lipoprotein, and low high-density lipoprotein. Despite this, patients with CGD had a 22% lower internal carotid artery wall volume compared with control subjects (361. 3±76. 4 mm(3) versus 463. 5±104. 7 mm(3); P<0. 001). This difference was comparable in p47(phox)- and gp91(phox)-deficient subtypes of CGD and independent of risk factors in multivariate regression analysis. In contrast, the prevalence of coronary arterial calcification was similar between patients with CGD and control subjects (14. 6%, CGD; 6. 3%, controls; P=0. 39). .

Conclusions: The observation by magnetic resonance imaging and computerized tomography of reduced carotid but not coronary artery atherosclerosis in patients with CGD despite the high prevalence of traditional risk factors raises questions about the role of NADPH oxidase in the pathogenesis of clinically significant atherosclerosis V体育ios版. Additional high-resolution studies in multiple vascular beds are required to address the therapeutic potential of NADPH oxidase inhibition in cardiovascular diseases. .

Clinical trial registration url: http://www. clinicaltrials. gov VSports最新版本. Unique identifier: NCT01063309. .

Keywords: atherosclerosis; carotid arteries; coronary vessels; immune system; inflammation. V体育平台登录.

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Conflict of interest statement (V体育ios版)

Conflict of Interest Disclosures: The content of this article does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U. S. Government. The authors report no conflict of interest relevant to the content of this manuscript VSports注册入口.

Figures

Figure 1
Figure 1
Comparison of Subclinical Coronary and Carotid Atherosclerosis in Healthy Controls and CGD Patients. Bars denote mean and 95% CI of the mean and p-values are from t-tests (Panels A, C) and ANOVA with a Holm-Šídák post-test (Panel B).
See this image and copyright information in PMC

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