Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or VSports app下载. mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. V体育官网.

Review
. 2014 Jul;6(3):139-50.
doi: 10.4103/0975-7406.130965.

Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues

Kanika Madaan  1 , Sandeep Kumar  1 , Neelam Poonia  1 , Viney Lather  2 , Deepti Pandita  1
Affiliations
Review

"VSports最新版本" Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues

Kanika Madaan et al. J Pharm Bioallied Sci. 2014 Jul.

"V体育官网入口" Abstract

Dendrimers are the emerging polymeric architectures that are known for their defined structures, versatility in drug delivery and high functionality whose properties resemble with biomolecules. These nanostructured macromolecules have shown their potential abilities in entrapping and/or conjugating the high molecular weight hydrophilic/hydrophobic entities by host-guest interactions and covalent bonding (prodrug approach) respectively. Moreover, high ratio of surface groups to molecular volume has made them a promising synthetic vector for gene delivery. Owing to these properties dendrimers have fascinated the researchers in the development of new drug carriers and they have been implicated in many therapeutic and biomedical applications VSports手机版. Despite of their extensive applications, their use in biological systems is limited due to toxicity issues associated with them. Considering this, the present review has focused on the different strategies of their synthesis, drug delivery and targeting, gene delivery and other biomedical applications, interactions involved in formation of drug-dendrimer complex along with characterization techniques employed for their evaluation, toxicity problems and associated approaches to alleviate their inherent toxicity. .

Keywords: Dendrimer; drug targeting; drug-dendrimer interactions; gene delivery; polyamidoamine. V体育安卓版.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Schematic representation of dendrimer components. Reproduced with permission from ref.,[7] Copyright 2005, Elsevier
Figure 2
Figure 2
Dendrimers as multifunctional nanoplatforms
Figure 3
Figure 3
Schematic representation of dendrimer synthesis by (a) Divergent and (b) Convergent methodologies
Figure 4
Figure 4
Schematic representation of polyamidoamine dendrimer-based gene delivery vectors. (a) Schematic illustration of the synthesis of dendrimer/RGD conjugates (pathway A + B) and of the indirect estimation of the number of pyridyldithiol (PDP) units per dendrimer by spectrophotometry (pathway A + C). Reproduced with permission from ref.,[68] Copyright 2011, American Chemical Society. (b) Strategy of synthesis followed in dendrimer surface functionalization with alkyl chains (activation of the fatty acid + conjugation reaction). Reproduced with permission from ref.,[69] Copyright 2010, Elsevier. (c) The two-step reaction for the synthesis of peptide-functionalized G5 PAMAM dendrimers (pathway A + B), and for indirect estimation of the number of peptide units by spectrophotometry (pathway A + C). Reproduced with permission from ref.,[70] Copyright 2010, American Chemical Society
Figure 5
Figure 5
Different types of drug-dendrimer interactions. The darkened oval represents an active substance. Reproduced with permission from ref.,[77] Copyright 2002, Elsevier
Figure 6
Figure 6
Various analytical techniques employed for the physicochemical characterization of dendrimers
See this image and copyright information in PMC

VSports注册入口 - References

    1. Hu CM, Aryal S, Zhang L. Nanoparticle-assisted combination therapies for effective cancer treatment. Ther Deliv. 2010;1:323–34. - PubMed
    1. Northfelt DW, Dezube BJ, Thommes JA, Miller BJ, Fischl MA, Friedman-Kien A, et al. Pegylated-liposomal doxorubicin versus doxorubicin, bleomycin, and vincristine in the treatment of AIDS-related Kaposi's sarcoma: Results of a randomized phase III clinical trial. J Clin Oncol. 1998;16:2445–51. - PubMed
    1. Harries M, Ellis P, Harper P. Nanoparticle albumin-bound paclitaxel for metastatic breast cancer. J Clin Oncol. 2005;23:7768–71. - PubMed
    1. Brannon-Peppas L, Blanchette JO. Nanoparticle and targeted systems for cancer therapy. Adv Drug Deliv Rev. 2004;56:1649–59. - PubMed (VSports app下载)
    1. Buhleier E, Wehner W, VÖGtle F. “Cascade”- and “nonskid-chain-like” a syntheses of molecular cavity topologies. Synthesis. 1978;2:155–8.

Publication types (V体育平台登录)