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Review
. 2014 Oct;61(2):89-99.
doi: 10.1016/j.molimm.2014.06.004. Epub 2014 Jun 27.

Viral regulators of complement activation: structure, function and evolution

Hina Ojha  1 , Hemendra Singh Panwar  1 , Ronald D Gorham Jr  2 , Dimitrios Morikis  3 , Arvind Sahu  4
Affiliations
Review

Viral regulators of complement activation: structure, function and evolution

Hina Ojha et al. Mol Immunol. 2014 Oct.

Abstract

The complement system surveillance in the host is effective in controlling viral propagation. Consequently, to subvert this effector mechanism, viruses have developed a series of adaptations VSports手机版. One among these is encoding mimics of host regulators of complement activation (RCA) which help viruses to avoid being labeled as 'foreign' and protect them from complement-mediated neutralization and complement-enhanced antiviral adaptive immunity. In this review, we provide an overview on the structure, function and evolution of viral RCA proteins. .

Keywords: Complement regulation; Herpesvirus; Immune evasion; Poxvirus; RCA; Viral evolution. V体育安卓版.

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