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Review
. 2014 Oct:34:9-14.
doi: 10.1016/j.semcdb.2014.05.015. Epub 2014 Jun 2.

Functional interactions among microRNAs and long noncoding RNAs

Je-Hyun Yoon  1 , Kotb Abdelmohsen  2 , Myriam Gorospe  3
Affiliations
Review

Functional interactions among microRNAs and long noncoding RNAs

VSports - Je-Hyun Yoon et al. Semin Cell Dev Biol. 2014 Oct.

Abstract

In mammals, the vast majority of transcripts expressed are noncoding RNAs, ranging from short RNAs (including microRNAs) to long RNAs spanning up to hundreds of kb. While the actions of microRNAs as destabilizers and repressors of the translation of protein-coding transcripts (mRNAs) have been studied in detail, the influence of microRNAs on long noncoding RNA (lncRNA) function is only now coming into view. Conversely, the influence of lncRNAs upon microRNA function is also rapidly emerging. In some cases, lncRNA stability is reduced through the interaction of specific miRNAs. In other cases, lncRNAs can act as microRNA decoys, with the sequestration of microRNAs favoring expression of repressed target mRNAs. Other lncRNAs derepress gene expression by competing with miRNAs for interaction with shared target mRNAs. Finally, some lncRNAs can produce miRNAs, leading to repression of target mRNAs VSports手机版. These microRNA-lncRNA regulatory paradigms modulate gene expression patterns that drive major cellular processes (such as cell differentiation, proliferation, and cell death) which are central to mammalian physiologic and pathologic processes. We review and summarize the types of microRNA-lncRNA crosstalk identified to-date and discuss their influence on gene expression programs. .

Keywords: Post-transcriptional gene regulation; RNA-binding protein; Ribonucleoprotein complex; Translation; mRNA stability. V体育安卓版.

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Figures

FIGURE 1
FIGURE 1. Modes of direct post-transcriptional interaction among lncRNAs and miRNAs
Schematic of the major forms of interplay among lncRNAs and miRNAs. (A) Some lncRNAs are degraded by miRNAs, as described for lincRNA-p21 (degraded by let-7), HOTAIR (by let-7), MALAT1 (by miR-9), LOC285194 (by miR-211), PTCSC3 (by miR-574-5p), H19 (by let-7), and lincRNA-RoR (by miR145-5p and miR-181a-5p). (B) Other lncRNAs can serve as sponges/decoys for microRNAs, as described for linc-MD1 (sequestering miR-133 and miR-135), circular RNAs (sequestering miR-7, although many more examples are predicted to occur), lincRNA-RoR (miR-145-5p), and H19 (let-7). (C) A few examples of lncRNAs that compete with miRNAs for binding to mRNAs have also been reported, including BACE1 AS, which competes with miR-485-5p for binding to BACE1 mRNA, and ncNRFR, which competes with let-7 to derepress let-7 site-bearing mRNAs to promote carcinogenesis. (D) Several lncRNAs also produce microRNAs and other small RNAs, as shown for linc-MD1, which generates miR-206 and miR-133b, H19 (generates miR-675), and RMRP (generates miRNAs RMRP-S1 and RMRP-S2). See text for details.
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