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. 2014 Aug 14;124(7):1174-82.
doi: 10.1182/blood-2014-02-554725. Epub 2014 Jun 17.

"V体育官网" The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation

Ying Taur  1 , Robert R Jenq  2 , Miguel-Angel Perales  3 , Eric R Littmann  4 , Sejal Morjaria  4 , Lilan Ling  5 , Daniel No  5 , Asia Gobourne  5 , Agnes Viale  6 , Parastoo B Dahi  3 , Doris M Ponce  3 , Juliet N Barker  3 , Sergio Giralt  3 , Marcel van den Brink  7 , Eric G Pamer  8
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The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation

Ying Taur et al. Blood. .

Abstract (VSports app下载)

Highly diverse bacterial populations inhabit the gastrointestinal tract and modulate host inflammation and promote immune tolerance. In allogeneic hematopoietic stem cell transplantation (allo-HSCT), the gastrointestinal mucosa is damaged, and colonizing bacteria are impacted, leading to an impaired intestinal microbiota with reduced diversity. We examined the impact of intestinal diversity on subsequent mortality outcomes following transplantation. Fecal specimens were collected from 80 recipients of allo-HSCT at the time of stem cell engraftment. Bacterial 16S rRNA gene sequences were characterized, and microbial diversity was estimated using the inverse Simpson index VSports手机版. Subjects were classified into high, intermediate, and low diversity groups and assessed for differences in outcomes. Mortality outcomes were significantly worse in patients with lower intestinal diversity; overall survival at 3 years was 36%, 60%, and 67% for low, intermediate, and high diversity groups, respectively (P = . 019, log-rank test). Low diversity showed a strong effect on mortality after multivariate adjustment for other clinical predictors (transplant related mortality: adjusted hazard ratio, 5. 25; P = . 014). In conclusion, the diversity of the intestinal microbiota at engraftment is an independent predictor of mortality in allo-HSCT recipients. These results indicate that the intestinal microbiota may be an important factor in the success or failure in allo-HSCT. .

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Figures

Figure 1
Figure 1
Kaplan-Meier plot of diversity and overall survival and transplant related mortality.
Figure 2
Figure 2
Intestinal microbiota at engraftment and subsequent transplant course by subject (N = 80). Each row represents a study subject. Horizontal stacked bars on the left side represent the phylogenetic composition of each subject at the time of stem cell engraftment. Microbial diversity, measured by inverse Simpson index, is listed in the next column. Timeline plots are shown in the next column; black lines represent survival time, closed circles represent death, and open circles represent censoring. Red x denotes relapse or progression of disease. For death events, cause of death is listed.
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References

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