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. 2014 Jun 7;20(21):6534-40.
doi: 10.3748/wjg.v20.i21.6534.

"V体育官网入口" Changes in iron transporter divalent metal transporter 1 in proximal jejunum after gastric bypass

Andrés Marambio  1 , Guillermo Watkins  1 , Fabiola Castro  1 , Andrea Riffo  1 , Roberta Zúñiga  1 , Jaime Jans  1 , María E Villanueva  1 , Guillermo Díaz  1
Affiliations

Changes in iron transporter divalent metal transporter 1 in proximal jejunum after gastric bypass

Andrés Marambio et al. World J Gastroenterol. .

Abstract

Aim: To describe the variation that divalent metal transporter 1 (DMT1) shows in patients after Roux-en-Y gastric bypass (RYGB) surgery. VSports手机版.

Methods: Prospective and analytical study of DMT1 level at the brush border of proximal jejunum in patients having undergone RYGB surgery V体育安卓版. The mucosa of proximal jejunum forming the gastrojejunal anastomosis was biopsied during surgery and after 6 mo later with an endoscopic biopsy. All the patients received precise instructions regarding feeding and nutritional supplementation. Both samples were processed at the same time by immunohistochemistry and western blot. Samples were analysed by a pathologist. For statistical analysis, the χ(2) and Wilcoxon tests were used. .

Results: Sixteen patients were recruited, 13 of whom completed the study. Twelve were women. Average age and body mass index (BMI) were 44 V体育ios版. 1 and 40. 4, respectively. Both body weight and BMI decreased significantly during the study period, with an average percent excess weight loss (%EWL) of 60% ± 13. 3% and an average percent excess BMI loss (%EBMIL) of 79. 6% ± 21. 6%. Only two patients presented with mild anaemia 6 mo after surgery, but their ferritin levels stayed within normal ranges. Staining for DMT1 showed a significant increase in the cytoplasm of enterocytes located at the tips of the villi (χ(2) = 6. 03; P = 0. 049). Nevertheless, the total quantity of DMT1 decreased significantly (Z = 2. 04; P = 0. 04). Associated with these results, we observed a significant increase in goblet cells in the villi 6 mo postoperatively (Z = -2. 47; P = 0. 013). .

Conclusion: Six months after RYGB surgery, patients exhibit an increase in DMT1 expression in the enterocytes of the tips of the villi at the proximal jejunum VSports最新版本. .

Keywords: Anaemia; Bariatric surgery; Divalent metal transporter 1; Iron; Roux-en-Y gastric bypass. V体育平台登录.

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Figures

Figure 1
Figure 1
Morphological and immunohistochemical changes in the jejunal villus of patients subjected to Roux-en-Y gastric bypass. A and B are jejunal villus stained with haematoxylin-eosin at 0 and 6 mo after surgery, respectively. Note the preserved normal morphological pattern together with an increase of goblet cells. C and D show immunohistochemical staining for divalent metal transporter 1 during the same period, with an evident increase of such staining in the cytoplasm of epithelial cells at the apex of the villi.
Figure 2
Figure 2
Change in the number of goblet cells in the proximal jejunum 6 mo after Roux-en-Y gastric bypass. Wilcoxon test: Z = -2.47; P = 0.013.
Figure 3
Figure 3
Change in expression of divalent metal transporter 1 in the proximal jejunum 6 mo after Roux-en-Y gastric bypass. Wilcoxon test: Z = 2.04; P = 0.04.
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References

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