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Randomized Controlled Trial
. 2014 Jul 31;124(5):812-21.
doi: 10.1182/blood-2013-11-536888. Epub 2014 May 22.

Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease (V体育2025版)

J Marius Munneke  1 , Andreas T Björklund  2 , Jenny M Mjösberg  2 , Karin Garming-Legert  3 , Jochem H Bernink  4 , Bianca Blom  5 , Cynthia Huisman  1 , Marinus H J van Oers  1 , Hergen Spits  5 , Karl-Johan Malmberg  6 , Mette D Hazenberg  1
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Randomized Controlled Trial

Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease

V体育平台登录 - J Marius Munneke et al. Blood. .
Free article

Abstract

Allogeneic hematopoietic stem cell transplantation (HSCT) is widely used to treat hematopoietic cell disorders but is often complicated by graft-versus-host disease (GVHD), which causes severe epithelial damage VSports手机版. Here we have investigated longitudinally the effects of induction chemotherapy, conditioning radiochemotherapy, and allogeneic HSCT on composition, phenotype, and recovery of circulating innate lymphoid cells (ILCs) in 51 acute leukemia patients. We found that reconstitution of ILC1, ILC2, and NCR(-)ILC3 was slow compared with that of neutrophils and monocytes. NCR(+) ILC3 cells, which are not present in the circulation of healthy persons, appeared both after induction chemotherapy and after allogeneic HSCT. Circulating patient ILCs before transplantation, as well as donor ILCs after transplantation, expressed activation (CD69), proliferation (Ki-67), and tissue homing markers for gut (α4β7, CCR6) and skin (CCR10 and CLA). The proportion of ILCs expressing these markers was associated with a decreased susceptibility to therapy-induced mucositis and acute GVHD. Taken together, these data suggest that ILC recovery and treatment-related tissue damage are interrelated and affect the development of GVHD. .

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