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. 2014 Apr 21;20(15):4421-7.
doi: 10.3748/wjg.v20.i15.4421.

Expression of monocyte chemotactic protein-1/CCL2 in gastric cancer and its relationship with tumor hypoxia

Lei-Lei Tao  1 , Shu-Jing Shi  1 , Long-Bang Chen  1 , Gui-Chun Huang  1
Affiliations

Expression of monocyte chemotactic protein-1/CCL2 in gastric cancer and its relationship with tumor hypoxia

Lei-Lei Tao et al. World J Gastroenterol. .

Abstract

Aim: To investigate the expression and prognostic value of CCL2 in gastric cancer, as well as its relationship with tumor hypoxia VSports手机版. .

Methods: Tumor tissues from 68 gastric cancer patients (GC) were analyzed, and the expression of CCL2 and hypoxia-inducible factor 1 alpha (HIF-1α) in tumor tissues was detected by immunohistochemistry. Statistical evaluations that were used included univariate log-rank tests of Kaplan-Meier curves and multivariate Cox regression model analysis V体育安卓版. .

Results: CCL2 was highly expressed in 66 V体育ios版. 2% (45/68) of gastric cancer specimens. The distribution of CCL2 expression in tumor tissue was consistent with that of HIF-1α. Patients with high CCL2 expression in GC had a lower overall survival rate [50. 6 mo (95%CI: 44. 44-56. 93) vs 64. 6 mo (95%CI: 60. 27-68. 94), P = 0. 013]. .

Conclusion: CCL2 expression correlates closely with HIF-1α expression in gastric cancer. CCL2 may be an independent prognostic marker for GC. VSports最新版本.

Keywords: Chemokines; Gastric cancer; Immunohistochemistry; Monocyte chemotactic protein-1/CCL2; Prognostic marker V体育平台登录. .

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Figures

Figure 1
Figure 1
The expression patterns of CCL2 and hypoxia-inducible factor 1α were detected in consecutive human gastric cancer tissues sections. A: Expression pattern of hypoxia-inducible factor 1 alpha (HIF-1α) in human gastric cancer tissues (100 ×); B: Expression pattern of CCL2 in the human gastric cancer tissues (400 ×). The spatial distribution of HIF-1α expression was consistent with that of CCL2 in tumor sections. (A-1 vs B-1, A-2 vs B-2).
Figure 2
Figure 2
Immunohistochemical detection of the expression pattern of CCL2 in human gastric cancer tissue. A: Expression pattern of CCL2 in gastric cancer (100 ×); C, E: Positive staining for CCL2; D, E: Expression pattern of CCL2 in gastric cancer (400 ×); The images in D and E are the amplified sections corresponding to B and C. B, D: Negative staining for CCL2.
Figure 3
Figure 3
Relationship between the expression of CCL2 and overall survival time in gastric cancer patients. Patients with high CCL2 expression had a poor overall survival [50.6 mo (95%CI: 44.44-56.93) vs 64.6 mo (95%CI: 60.27-68.94), P = 0.013].
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References

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