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. 2014 Jun;11(6):637-40.
doi: 10.1038/nmeth.2930. Epub 2014 Apr 20.

"V体育ios版" Validation of noise models for single-cell transcriptomics

Dominic Grün  1 , Lennart Kester  1 , Alexander van Oudenaarden  2
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Validation of noise models for single-cell transcriptomics

Dominic Grün et al. Nat Methods. 2014 Jun.

Abstract

Single-cell transcriptomics has recently emerged as a powerful technology to explore gene expression heterogeneity among single cells. Here we identify two major sources of technical variability: sampling noise and global cell-to-cell variation in sequencing efficiency. We propose noise models to correct for this, which we validate using single-molecule FISH. We demonstrate that gene expression variability in mouse embryonic stem cells depends on the culture condition. VSports手机版.

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References

    1. Nature. 2010 Sep 9;467(7312):167-73 - "VSports手机版" PubMed
    1. Nat Methods. 2005 Oct;2(10):731-4 - PubMed
    1. Bioinformatics. 2010 Mar 1;26(5):589-95 - PubMed
    1. Nat Methods. 2008 Oct;5(10):877-9 - PubMed (VSports手机版)
    1. Nat Methods. 2013 Nov;10(11):1096-8 - PubMed

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