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Comparative Study
. 2014 Jun;164(6):1403-8.e1.
doi: 10.1016/j.jpeds.2014.02.026. Epub 2014 Mar 20.

Bisphenol A exposure is associated with decreased lung function

Adam J Spanier  1 , Elizabeth K Fiorino  2 , Leonardo Trasande  3
Affiliations
Comparative Study

Bisphenol A exposure is associated with decreased lung function (V体育安卓版)

VSports手机版 - Adam J Spanier et al. J Pediatr. 2014 Jun.

Abstract

Objective: To examine the associations of bisphenol A (BPA) exposure with lung function measures and exhaled nitric oxide (FeNO) in children. VSports手机版.

Study design: We performed a cross-sectional analysis of a subsample of US children age 6-19 years who participated in the 2007-2010 National Health and Nutrition Examination Survey. We assessed univariate and multivariable associations of urinary BPA concentration with the predicted pulmonary function measures for age, sex, race/ethnicity and height (forced expiratory volume in 1 second [FEV1], forced vital capacity [FVC], forced expiratory flow 25%-75%, and FEV1 divided by FVC) and with FeNO V体育安卓版. .

Results: Exposure and outcome data were available for 661 children. Median BPA was 2. 4 ng/mL (IQR: 1. 3, 4. 1). In multivariable analysis, a larger urinary BPA concentration was associated with significantly decreased percent predicted forced expiratory flow 25%-75% (%FEF2575) (3. 7%, 95% CI 1. 0, 6 V体育ios版. 5) and percent predicted FEV1 divided by FVC (%FEV1/FVC) (0. 8%, 95% CI 0. 1, 1. 7) but not percent predicted FEV1, percent predicted FVC, or FeNO. A child in the top quartile of BPA compared with the bottom quartile had a 10% decrease in %FEF2575 (95% CI -1, -19) and 3% decrease in %FEV1/FVC (95% CI -1, -5). .

Conclusions: BPA exposure was associated with a modest decrease in %FEF2575 (small airway function) and %FEV1/FVC (pulmonary obstruction) but not FEV1, FVC, or FeNO. Explanations of the association cannot rule out the possibility of reverse causality. VSports最新版本.

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Conflict of interest statement

The authors declare no conflicts of interest.

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