Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in VSports app下载. gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely V体育官网. .

Review
. 2014:32:323-66.
doi: 10.1146/annurev-immunol-032713-120243. Epub 2014 Jan 31.

Biology of CD1- and MR1-restricted T cells

Mariolina Salio  1 , Jonathan D Silk, E Yvonne Jones, Vincenzo Cerundolo
Affiliations
Review

Biology of CD1- and MR1-restricted T cells

Mariolina Salio et al. Annu Rev Immunol. 2014.

Abstract

Over the past 15 years, investigators have shown that T lymphocytes can recognize not only peptides in the context of MHC class I and class II molecules but also foreign and self-lipids in association with the nonclassical MHC class I-like molecules, CD1 proteins. In this review, we describe the most recent events in the field, with particular emphasis on (a) structural and functional aspects of lipid presentation by CD1 molecules, (b) the development of CD1d-restricted invariant natural killer T (iNKT) cells and transcription factors required for their differentiation, (c) the ability of iNKT cells to modulate innate and adaptive immune responses through their cross talk with lymphoid and myeloid cells, and (d) MR1-restricted and group I (CD1a, CD1b, and CD1c)-restricted T cells. VSports手机版.

PubMed Disclaimer

"VSports" MeSH terms

"V体育官网" LinkOut - more resources