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Comparative Study
. 2014 Jan 22:4:3814.
doi: 10.1038/srep03814.

Fecal microbiota imbalance in Mexican children with type 1 diabetes

María Esther Mejía-León  1 , Joseph F Petrosino  2 , Nadim Jose Ajami  2 , María Gloria Domínguez-Bello  3 , Ana María Calderón de la Barca  1
Affiliations
Comparative Study

"VSports注册入口" Fecal microbiota imbalance in Mexican children with type 1 diabetes

VSports手机版 - María Esther Mejía-León et al. Sci Rep. .

Abstract

Dysbiosis of the intestinal microbiota affecting the gut barrier could be triggering Type 1 Diabetes (T1D), the second most frequent autoimmune disease in childhood. This study compared the structure of the fecal microbiota in 29 mestizo children aged 7-18 years, including 8 T1D at onset, 13 T1D after 2 years treatment, and 8 healthy controls. Clinical information was collected, predisposing haplotypes were determined; the fecal DNA was extracted, the V4 region of the 16S rRNA gene amplified and 454-pyrosequenced. The newly diagnosed T1D cases had high levels of the genus Bacteroides (p < 0. 004), whereas the control group had a gut microbiota dominated by Prevotella. Children with T1D treated for ≥2 years had levels of Bacteroides and Prevotella compared to those of the control group VSports手机版. The gut microbiota of newly diagnosed T1D cases is altered, but whether it is involved in disease causation or is a consequence of host selection remains unclear. .

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Figures

Figure 1
Figure 1. Diversity of the microbiota in T1D and healthy children.
(A) Rarefaction curves of phylogenetic diversity in fecal samples (Student's t test); (B) Principal Coordinate Analysis of fecal communities weighted Unifrac distances in T1D and healthy children.
Figure 2
Figure 2. Weighted UniFrac distances between groups.
*p,0.00005, **p,0.000005, NS: non-significant (Student's t test).
Figure 3
Figure 3. Average relative bacterial abundance of taxa in the fecal microbiota of healthy or T1D children.
Relative abundance of fecal bacterial phyla (A) or genera (B) in each subject. Pie charts (C) depict phylum (outer ring) and genus (pie) level distribution. The proportions of the genus relative abundance are showed in the table and the p values of ANOVA, Tukey-Kramer test refer to the comparison between the 3 groups. In this analysis only phyla and genera with relative abundance greater than 1% were included. All OTUs with lower abundance were grouped as “other”.
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References

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