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. 2012 Nov 2:2:190-5.
doi: 10.1016/j.rinim.2012.10.003. eCollection 2012.

VSports最新版本 - Circulating interleukin-8 and plasminogen activator inhibitor-1 are increased in women with ovarian carcinoma

Guro Aune  1 , Astrid Kamilla Stunes  1 , Aina-Mari Lian  2 , Janne Elin Reseland  2 , Solveig Tingulstad  3 , Sverre H Torp  4 , Unni Syversen  5
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V体育ios版 - Circulating interleukin-8 and plasminogen activator inhibitor-1 are increased in women with ovarian carcinoma

Guro Aune (VSports手机版) et al. Results Immunol. .

Abstract

Elevated serum levels of several cytokines have been reported in ovarian cancer VSports手机版. We have previously found a diagnostic and prognostic value of hepatocyte growth factor (HGF). The aims of this study were to evaluate the diagnostic and prognostic value of multiple serum cytokines in women with ovarian tumors, and to examine possible associations between serum levels of cytokines and the previously analyzed HGF. Preoperative levels of multiple cytokines were quantified by serum-based immunoassays in 113 women with a pelvic mass: 57 carcinomas, 23 borderline tumors, and 33 benign ovarian tumors. The results were related to clinicopathological parameters. Univariate and multivariate analyses of five-year overall survival were performed. The women with ovarian carcinoma had significantly higher preoperative serum levels of cancer antigen 125 (CA 125), interleukin 8 (IL-8), and plasminogen activator inhibitor-1 (PAI-1) than women with benign ovarian tumors. Serum IL-8 and PAI-1 levels were positively correlated to serum levels of HGF. In a multivariate analysis of five-year overall survival, IL-8 had a prognostic impact. Serum levels of IL-8 and PAI-1 were elevated in women with ovarian carcinoma compared to women with benign ovarian tumors, and positively correlated to serum HGF levels in women with ovarian tumors. IL-8 also seemed to have a prognostic impact. .

Keywords: Hepatocyte growth factor; Interleukin-8; Ovarian cancer; Plasma markers; Plasminogen activator inhibitor-1 V体育安卓版. .

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Figures

Fig. 1
Fig. 1
Median serum levels and range of (A) CA 125, (B) HGF, (C) IL-8, (D) PAI-1, (E) leptin, (F) resistin and (G) adiponectin levels in patients with carcinoma, borderline, and benign tumors of the ovary (N = 113). *: comparison carcinomas/benign; ‡: comparison carcinomas/borderline; †: comparison borderline/benign, significant differences, p<0.05.
Fig. 2
Fig. 2
5-year survival in advanced stage epithelial ovarian cancer in cases ≤2SD and >2SD from reference value.
See this image and copyright information in PMC

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