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. 2014 Jan 13:558:37-40.
doi: 10.1016/j.neulet.2013.10.058. Epub 2013 Nov 7.

Klotho in the cerebrospinal fluid of adults with and without Alzheimer's disease

Richard D Semba  1 , Abhay R Moghekar  2 , Jason Hu  2 , Kai Sun  2 , Randi Turner  2 , Luigi Ferrucci  3 , Richard O'Brien  2
Affiliations

Klotho in the cerebrospinal fluid of adults with and without Alzheimer's disease (VSports注册入口)

Richard D Semba (V体育平台登录) et al. Neurosci Lett. .

Abstract

The aging-suppressor gene klotho encodes a single-pass transmembrane protein that is predominantly secreted by the choroid plexus of the brain and in the kidney. Klotho-deficient mice develop multiple aging phenotypes, including impaired cognition. Klotho concentrations have not been described in the CSF of humans. We measured klotho in the CSF of 20 older adults with Alzheimer's disease and in 20 older and 20 younger adults with normal cognition. In 10 adults, aged 38-87 years, CSF klotho measurements were made at baseline and every 6h up to 18-30 h later. Mean (95% confidence interval [C. I VSports手机版. ]) CSF klotho in men versus women were 899 (814, 983) and 716 (632, 801) pg/mL, respectively (P=0. 002). Mean (95% C. I. ) CSF klotho in older adults with and without Alzheimer's disease were 664 (603, 725) and 776 (705, 828) pg/mL, respectively (P=0. 02), adjusting for sex. Mean (95% C. I. ) klotho in older versus younger adults were 766 (658, 874) and 992 (884, 1100) pg/mL, respectively (P=0. 005), adjusting for sex. In the longitudinal study of CSF klotho, no significant circadian fluctuations were found in CSF klotho levels. This study suggests that CSF klotho concentrations are lower in females compared with males, in Alzheimer's disease, and in older versus younger adults. .

Keywords: Aging; Alzheimer's disease; Brain; Cerebrospinal fluid; Klotho. V体育安卓版.

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Figures

Figure 1
Figure 1
CSF klotho concentrations in men versus women. Boxplots represent median (25th, 75th percentile) and bars represent maximum and minimum values.
Figure 2
Figure 2
Scatterplot of MMSE score versus CSF klotho concentrations.
Figure 3
Figure 3
CSF Klotho concentrations over time in ten adults.
See this image and copyright information in PMC

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