HLA-G regulates the invasive properties of JEG-3 choriocarcinoma cells by controlling STAT3 activation
- PMID: 24054889
- DOI: 10.1016/j.placenta.2013.07.070
HLA-G regulates the invasive properties of JEG-3 choriocarcinoma cells by controlling STAT3 activation
Abstract
The expression of human leucocyte antigen-G (HLA-G) in trophoblasts plays a crucial role in successful embryonic implantation, and reduced HLA-G expression might contribute to adverse obstetric outcomes VSports手机版. In this study, we silenced HLA-G expression using RNA interference in JEG-3 cells, resulting in a notably attenuated invasion capacity of the cells in a Transwell assay; however, no alterations in cell proliferation or apoptosis were observed. The down-regulation of HLA-G dampened the activation of signal transducer and activator of transcription 3 (STAT3), whereas the up-regulation of HLA-G promoted STAT3 activation and invasion in JEG-3 cells treated with human galectin-1. Most importantly, interleukin-6 (IL-6), but not galectin-1, was shown to rescue invasion deficiency in a dose-dependent manner. Thus, we demonstrate that HLA-G is able to regulate JEG-3 cell invasion by influencing STAT3 activation, which may underlie the implantation defects accompanying HLA-G hypo-expression in pre-eclampsia. .
Keywords: HLA-G; Human galectin-1; IL-6; JEG-3; STAT3; Trophoblast invasion. V体育安卓版.
Copyright © 2013 Elsevier Ltd. All rights reserved. V体育ios版.
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