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. 2013 Oct;102(4):278-87.
doi: 10.1016/j.ygeno.2013.07.006. Epub 2013 Jul 21.

"V体育官网" Genome-wide association study in breast cancer survivors reveals SNPs associated with gene expression of genes belonging to MHC class I and II

Hege Landmark-Høyvik  1 , Vanessa Dumeaux, Daniel Nebdal, Eiliv Lund, Jörg Tost, Yoichiro Kamatani, Victor Renault, Anne-Lise Børresen-Dale, Vessela Kristensen, Hege Edvardsen
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Genome-wide association study in breast cancer survivors reveals SNPs associated with gene expression of genes belonging to MHC class I and II

Hege Landmark-Høyvik et al. Genomics. 2013 Oct.
Free article

VSports - Abstract

Introduction: We investigated the effect of genetic variation on gene expression in blood from a cohort of BC survivors VSports手机版. Further, we investigated the associations that were specific for BC survivors by performing identical analyses for a group of healthy women and comparing the results. .

Methods: eQTL analysis was performed for 288 BC survivors (full data set) V体育安卓版. Further, using a subset of the data, eQTL analyses were performed on 288 BC survivors and on 81 healthy women separately and results were compared. .

Results: A large number of associations were observed for the BC survivors, and the expression of human leukocyte antigen genes was found associated with SNPs in 100 genes. The comparison analyses with healthy women revealed associations occurring specifically in BC survivors, and the genes showed enrichment for immune system processes V体育ios版. .

Conclusions: The results suggest that the immune system has a different constitution in BC survivors compared to healthy women VSports最新版本. .

Keywords: BC; Breast cancer; Breast cancer survivors; FDR; Gene expression; HLA; IPA; LD; MHC; Radiotherapy; SNP; Treatment; UTR; breast cancer; chr; chromosome; eQTL; false discovery rate; human leukocyte antigen; ingenuity pathway analysis; linkage disequilibrium; mRNA; major histocompatibility; messenger RNA; single nucleotide polymorphism; untranslated region V体育平台登录. .

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