Effector-like CD8⁺ T cells in the memory population mediate potent protective immunity (V体育官网)
- PMID: 23746652
- PMCID: "V体育官网" PMC3703254
- DOI: "V体育ios版" 10.1016/j.immuni.2013.05.009
Effector-like CD8⁺ T cells in the memory population mediate potent protective immunity (V体育安卓版)
Abstract
The CD8⁺ memory T cell population is heterogeneous, and it is unclear which subset(s) optimally mediate the central goal of the immune system-protection against infection. Here we investigate the protective capacities of CD8⁺ T cell subsets present at the memory stage of the immune response. We show that a population of CD8⁺ T cells bearing markers associated with effector cells (KLRG1(hi), CD27(lo), T-bet(hi), Eomes(lo)) persisted to the memory phase and provided optimal control of Listeria monocytogenes and vaccinia virus, despite weak recall proliferative responses VSports手机版. After antigen-specific boosting, this population formed the predominant secondary memory subset and maintained superior pathogen control. The effector-like memory subset displayed a distinct pattern of tissue distribution and localization within the spleen, and their enhanced capacity to eliminate Listeria involved specialized utilization of cytolysis. Together, these data suggest that long-lived effector CD8⁺ T cells are optimal for protective immunity against certain pathogens. .
Copyright © 2013 Elsevier Inc. All rights reserved. V体育安卓版.
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Comment in (VSports注册入口)
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Instant recall: a key role for effector-phenotype CD8⁺ memory T cells in immune protection.Immunity. 2013 Jun 27;38(6):1090-1. doi: 10.1016/j.immuni.2013.06.007. Immunity. 2013. PMID: 23809159
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