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. 2013 Jun 28;436(2):319-24.
doi: 10.1016/j.bbrc.2013.05.101. Epub 2013 Jun 4.

VSports最新版本 - Large noncoding RNA HOTAIR enhances aggressive biological behavior and is associated with short disease-free survival in human non-small cell lung cancer

Takayuki Nakagawa  1 , Hiroyuki Endo, Misa Yokoyama, Jiro Abe, Keiichi Tamai, Nobuyuki Tanaka, Ikuro Sato, Satomi Takahashi, Takashi Kondo, Kennichi Satoh
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Large noncoding RNA HOTAIR enhances aggressive biological behavior and is associated with short disease-free survival in human non-small cell lung cancer

VSports在线直播 - Takayuki Nakagawa et al. Biochem Biophys Res Commun. .

Abstract

HOTAIR is one of long non-coding RNAs and its expression correlates with the prognosis and metastasis in various cancers VSports手机版. We showed that HOTAIR expression has an important role in the development of non-small cell lung cancer (NSCLC). In this study, we examined the expression of HOTAIR in 77 NSCLCs, their corresponding normal lung tissues and 6 brain metastases by quantitative real-time RT-PCR. High expression of HOTAIR (tumor/normal ratio ⩾2) was detected in 17 patients (22. 1%) and was frequently found in patients with advanced stage, lymph node metastasis or lymph-vascular invasion and short disease free interval. Furthermore, brain metastases show significantly higher HOTAIR expression compared to primary cancer tissues. HOTAIR-expressing A549 cells showed induced cell migration and anchorage-independent cell growth in vitro. These results indicate the expression of HOTAIR enhanced the aggressive behavior of NSCLC cells. .

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