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. 2013 Apr;33(4):1409-14.

Association of copper transporter expression with platinum resistance in epithelial ovarian cancer

Hiroyuki Yoshida  1 , Masatomo Teramae, Makoto Yamauchi, Takeshi Fukuda, Tomoyo Yasui, Toshiyuki Sumi, Ken-Ichi Honda, Osamu Ishiko
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  • PMID: 23564780

Association of copper transporter expression with platinum resistance in epithelial ovarian cancer

Hiroyuki Yoshida et al. Anticancer Res. 2013 Apr.

"V体育2025版" Abstract

Background: Copper transporters (CTR) also regulate the cellular transport of platinum drugs, but their role in platinum resistance of ovarian cancer has not been elucidated VSports手机版. .

Materials and methods: CTR expression in ovarian cancer tissues resected from patients treated by platinum-based chemotherapy was evaluated immunohistochemically. CTR2 expression in ovarian cancer cells was inhibited by bathocuproine disulfonate, and the changes in cisplatin sensitivity were examined V体育安卓版. .

Results: CTR2 expression was increased in chemoresistant patients, but not significantly. However, the CTR2/CTR1 ratio was significantly increased in chemoresistant patients. Cases with positive CTR2 expression or positive CTR2/CTR1 ratio had poor prognoses. When the CTR2 expression in ovarian cancer cells was suppressed, sensitivity to cisplatin was significantly increased. V体育ios版.

Conclusion: These data suggest that CTR2 contributes to platinum resistance in ovarian cancer. The CTR2/CTR1 ratio is a useful marker for platinum sensitivity and a potential prognostic factor in patients with ovarian cancer VSports最新版本. .

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