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. 2013 May;8(5):781-6.
doi: 10.2215/CJN.09570912. Epub 2013 Jan 18.

"VSports在线直播" Serum FGF23 and risk of cardiovascular events in relation to mineral metabolism and cardiovascular pathology

Johan Ärnlöv  1 , Axel C Carlsson, Johan Sundström, Erik Ingelsson, Anders Larsson, Lars Lind, Tobias E Larsson
Affiliations

"V体育2025版" Serum FGF23 and risk of cardiovascular events in relation to mineral metabolism and cardiovascular pathology

Johan Ärnlöv et al. Clin J Am Soc Nephrol. 2013 May.

Abstract

Background and objectives: Circulating fibroblast growth factor-23 is associated with adverse cardiovascular outcomes in CKD and non-CKD individuals, but the underlying mechanism remains unclear VSports手机版. This study tested whether this association is independent of mineral metabolism and indices of subclinical cardiovascular pathology. .

Design, setting, participants, & measurements: The prospective association between fibroblast growth factor-23 and major cardiovascular events (a composite of hospital-treated myocardial infarction, hospital-treated stroke, or all-cause mortality) was investigated in the community-based Prospective Investigation of the Vasculature in Uppsala Seniors (n=973; mean age=70 years, 50% women) using multivariate logistic regression V体育安卓版. Subjects were recruited between January of 2001 and June of 2004. .

Results: During follow-up (median=5. 1 years), 112 participants suffered a major cardiovascular event. In logistic regression models adjusted for age, sex, and estimated GFR, higher fibroblast growth factor-23 was associated with increased risk for major cardiovascular events (odds ratio for tertiles 2 and 3 versus tertile 1=1. 92, 95% confidence interval=1. 19-3. 09, P<0. 01). After additional adjustments in the model, adding established cardiovascular risk factors, confounders of mineral metabolism (calcium, phosphate, parathyroid hormone, and 25(OH)-vitamin D), and indices of subclinical pathology (flow-mediated vasodilation, endothelial-dependent and -independent vasodilation, arterial stiffness, and atherosclerosis and left ventricular mass) attenuated this relationship, but it remained significant (odds ratio for tertiles 2 and 3 versus tertile 1=1. 69, 95% confidence interval=1. 01-2. 82, P<0 V体育ios版. 05). .

Conclusions: Fibroblast growth factor-23 is an independent predictor of cardiovascular events in the community, even after accounting for mineral metabolism abnormalities and subclinical cardiovascular damage. Circulating fibroblast growth factor-23 may reflect novel and important aspects of cardiovascular risk yet to be unraveled. VSports最新版本.

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V体育官网入口 - References

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