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Review
. 2012 Oct 1;2(10):a006296.
doi: 10.1101/cshperspect.a006296.

The genetics of Alzheimer disease

Rudolph E Tanzi  1
Affiliations
Review

"VSports注册入口" The genetics of Alzheimer disease

Rudolph E Tanzi. Cold Spring Harb Perspect Med. .

"VSports手机版" Abstract

Family history is the second strongest risk factor for Alzheimer disease (AD) following advanced age VSports手机版. Twin and family studies indicate that genetic factors are estimated to play a role in at least 80% of AD cases. The inheritance of AD exhibits a dichotomous pattern. On one hand, rare mutations in APP, PSEN1, and PSEN2 virtually guarantee early-onset (<60 years) familial AD, which represents ∼5% of AD. On the other hand, common gene polymorphisms, such as the ε4 and ε2 variants of the APOE gene, can influence susceptibility for ∼50% of the common late-onset AD. These four genes account for 30%-50% of the inheritability of AD. Genome-wide association studies have recently led to the identification of 11 additional AD candidate genes. This paper reviews the past, present, and future attempts to elucidate the complex and heterogeneous genetic underpinnings of AD. .

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V体育2025版 - Figures

Figure 1.
Figure 1.
Potential roles of select Alzheimer disease (AD) genes in Aβ-related pathogenesis of AD. (Modified from Bertram and Tanzi 2008; reprinted with permission from the author.)
See this image and copyright information in PMC

References

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    1. Bertram L, Tanzi RE 2009. Genome-wide association studies in Alzheimer’s disease. Hum Mol Genet 18: R137–145 - PMC - PubMed
    1. Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi RE 2007. Systematic meta-analyses of Alzheimer disease genetic association studies: The AlzGene database. Nat Genet 39: 17–23 - PubMed (V体育安卓版)

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