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. 2012 Aug 15;206(4):504-11.
doi: 10.1093/infdis/jis398. Epub 2012 Jun 13.

Active squamous metaplasia of the cervical epithelium is associated with subsequent acquisition of human papillomavirus 16 infection among healthy young women

Loris Y Hwang  1 , Yifei Ma, Stephen C Shiboski, Sepideh Farhat, Janet Jonte, Anna-Barbara Moscicki
Affiliations

Active squamous metaplasia of the cervical epithelium is associated with subsequent acquisition of human papillomavirus 16 infection among healthy young women

Loris Y Hwang et al. J Infect Dis. .

Abstract

Background: Vulnerability of younger women to human papillomavirus 16 (HPV16) infection has been attributed to the predominance of ectocervical columnar epithelia in this age group. However, squamous metaplastic tissue may be more influential. We examined the extent of ectopy and metaplastic activity as risks for HPV16 acquisition in a prospective cohort VSports手机版. .

Methods: Participants were HPV16 negative at the first two visits. Follow-up occurred every 4 months. Ectopy was quantitatively measured on colpophotographs. We calculated metaplastic rate as the difference in ectopy between visits. Cox proportional hazards models were constructed, adjusting for several covariates. V体育安卓版.

Results: Analyses included 198 women (mean baseline age 17 years) for 1734 visits. Mean follow-up was 4. 4 years. Incident HPV16 was detected in 36 (18%) women. Metaplastic rate between the two visits before HPV16 detection was significantly associated with incident infection (hazard ratio [HR], 1. 17; confidence interval [CI], 1. 02-1. 33; P = V体育ios版. 02). However, ectopy was not significant, whether measured before or concurrent to HPV16 detection (HR range, 0. 99-1. 00; CI range, . 97-1. 02; P range, . 47-. 65). .

Conclusions: Dynamic metaplasia rather than the sheer extent of ectopy appears to increase risk for incident HPV16 in healthy young women. This in vivo observation is consistent with the HPV life cycle, during which host cell replication and differentiation supports viral replication VSports最新版本. .

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Figures

Figure 1.
Figure 1.
Colpophotographs taken at consecutive visits for 1 woman. Ectopy, defined as areas of columnar and early-mid-metaplastic epithelium, is shown here by a manual outline (solid black line) and measured as a percentage of the total cervical face. A, Ectopy is 62% at visit 1. B, Ectopy is 25% at visit 2. C, Ectopy is 9% at visit 3. For this woman, HPV 16 DNA detection by cervical sampling was negative at visits 1 and 2 and positive at visit 3.
See this image and copyright information in PMC

References

    1. Centers for Disease Control and Prevention. Sexually transmitted disease surveillance, 2009. Atlanta, Georgia: U.S. Department of Health and Human Services; 2010.
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    1. Clifford GM, Smith JS, Plummer M, Muñoz N, Franceschi S. Human papillomavirus types in invasive cervical cancer worldwide: a meta-analysis. Br J Cancer. 2003;88:63–73. - VSports注册入口 - PMC - PubMed
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