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Review
. 2012 May 14:5:15.
doi: 10.1186/1756-6606-5-15.

Caspases in synaptic plasticity

Affiliations
Review

Caspases in synaptic plasticity (VSports)

"V体育安卓版" Zheng Li et al. Mol Brain. .

Abstract

Caspases are a family of cysteine proteases that play key roles in programmed cell death (apoptosis) VSports手机版. Mounting evidence in recent years shows that caspases also have important non-apoptotic functions in multiple cellular processes, such as synaptic plasticity, dendritic development, learning and memory. In this article, we review the studies on the non-apoptotic functions of caspases in neurons, with a focus on their roles in synaptic plasticity, learning and memory and neurodegeneration. .

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Figures

Figure 1
Figure 1
Extrinsic and intrinsic pathways of apoptosis. The two major apopotosis pathways are illustrated. The extrinsic pathway is initiated by ligand binding to death receptors on the plasma membrane. The intrinsic pathway is also called the mitochondrial pathway. Both pathways lead to activation of caspases.
Figure 2
Figure 2
Involvement of mitochondria and intrinsic apoptotic pathway in LTD. The mitochondrial pathway is required for NMDA receptor-dependent long-term depression of synaptic transmission. NMDA receptor activation leads to moderate activation of the mitochondrial pathway, which is required for AMPA receptor endocytosis.

References (VSports在线直播)

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