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. 2012;7(4):e35145.
doi: 10.1371/journal.pone.0035145. Epub 2012 Apr 6.

A genetic variant in long non-coding RNA HULC contributes to risk of HBV-related hepatocellular carcinoma in a Chinese population

Yao Liu  1 , Shandong Pan, Li Liu, Xiangjun Zhai, Jibin Liu, Juan Wen, Yixin Zhang, Jianguo Chen, Hongbing Shen, Zhibin Hu
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A genetic variant in long non-coding RNA HULC contributes to risk of HBV-related hepatocellular carcinoma in a Chinese population (V体育ios版)

Yao Liu et al. PLoS One. 2012.

Abstract

Background: Recently, several studies have demonstrated that two long non-coding RNAs (lncRNAs), HULC and MALAT1, may participate in hepatocellular carcinoma (HCC) development and progression. However, genetic variations in the two lncRNAs and their associations with HCC susceptibility have not been reported. In this study, we hypothesized that single nucleotide polymorphisms (SNPs) in HULC and MALAT1 may contribute to HCC risk. VSports手机版.

Methods: We conducted a case-control study and genotyped two SNPs, rs7763881 in HULC and rs619586 in MALAT1, in 1300 HBV positive HCC patients, 1344 HBV persistent carriers and 1344 subjects with HBV natural clearance to test the associations between the two SNPs and susceptibility to HCC and HBV chronic infection V体育安卓版. .

Results: The variant genotypes of rs7763881 were significantly associated with decreased HCC risk in a dominant genetic model [AC/CC vs. AA: adjusted odds ration (OR) = 0. 81, 95% confidence intervals (CIs) = 0. 68-0. 97, P = 0. 022]. Furthermore, the variant genotypes of rs619586 was associated with decreased HCC risk with a borderline significance (AG/GG vs. AA: adjusted OR = 0. 81, 95% CIs = 0. 65-1 V体育ios版. 01, P = 0. 057). However, no significant association was found between the two SNPs and HBV clearance. .

Conclusions: The variant genotypes of rs7763881 in HULC may contribute to decreased susceptibility to HCC in HBV persistent carriers. VSports最新版本.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

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