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. 2012:2012:525098.
doi: 10.1155/2012/525098. Epub 2012 Mar 5.

Confocal Laser Endomicroscopy in the Study of Colonic Mucosa in IBD Patients: A Review (VSports app下载)

Francesca Salvatori  1 , Saverio Siciliano, Francesco Maione, Dario Esposito, Stefania Masone, Marcello Persico, Giovanni D De Palma
Affiliations

Confocal Laser Endomicroscopy in the Study of Colonic Mucosa in IBD Patients: A Review

Francesca Salvatori (V体育安卓版) et al. Gastroenterol Res Pract. 2012.

Abstract (V体育官网)

Confocal laser endomicroscopy (CLE) is one of several novel methods that provide real-time, high-resolution imaging at a micronscale via endoscopes. CLE and related technologies are often termed "virtual biopsy" as they simulate the images seen in traditional histology. Recently, the use of CLE was reported in the study of colonic mucosa in patients with inflammatory bowel diseases and in particular in patients affected by ulcerative colitis. CLE has the potential to have an important role in management of IBD patients as it can be used to assess the grading of colitis and in detection of microscopic colitis in endoscopically silent segments. Moreover, CLE can be used in surveillance programs especially in high-risk patients VSports手机版. This report aims to evaluate the current data on the application of confocal endomicroscopy in clinical gastroenterology and particularly in the study of colonic mucosa in UC patients. .

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Figures

Figure 1
Figure 1
p-CLE fluorescein sodium 10% imaging of the normal colon showing hexagonal, honeycomb appearance with a regular-ordered network of capillaries demarcating the luminal crypt orifice. Surface crypt architecture was classically represented by ordered and regular crypt orifices covered by a homogeneous epithelial layer with visible “black-hole” goblet cells within the subcellular matrix.
Figure 2
Figure 2
p-CLE fluorescein sodium 10% imaging examples of crypt types of patients in active ulcerative colitis. (a) crypt fusion and distortion; (b) dilation of crypt openings, with fluorescein leaks into the crypt lumen therefore making the lumen brighter than the surrounding epithelium.
Figure 3
Figure 3
p-CLE fluorescein sodium 10% imaging of vessel architecture in ulcerative colitis: preserved hexagonal, honeycomb appearance with slightly dilated capillaries.
Figure 4
Figure 4
p-CLE fluorescein sodium 10% imaging of dysplastic epithelium in ulcerative colitis. (a) the architectural pattern of crypt is irregular, with epithelial thickness, villiform structures, and “dark” epithelial border. (b) the vessel architecture shows tortuous and dilated capillaries.
See this image and copyright information in PMC

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