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. 2012 Feb 12;14(3):249-56.
doi: 10.1038/ncb2441.

"VSports手机版" Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs

Eduard Hergenreider  1 , Susanne Heydt, Karine Tréguer, Thomas Boettger, Anton J G Horrevoets, Andreas M Zeiher, Margot P Scheffer, Achilleas S Frangakis, Xiaoke Yin, Manuel Mayr, Thomas Braun, Carmen Urbich, Reinier A Boon, Stefanie Dimmeler
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Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs

Eduard Hergenreider et al. Nat Cell Biol. .

"VSports手机版" Abstract

The shear-responsive transcription factor Krüppel-like factor 2 (KLF2) is a critical regulator of endothelial gene expression patterns induced by atheroprotective flow. As microRNAs (miRNAs) post-transcriptionally control gene expression in many pathogenic and physiological processes, we investigated the regulation of miRNAs by KLF2 in endothelial cells. KLF2 binds to the promoter and induces a significant upregulation of the miR-143/145 cluster. Interestingly, miR-143/145 has been shown to control smooth muscle cell (SMC) phenotypes; therefore, we investigated the possibility of transport of these miRNAs between endothelial cells and SMCs VSports手机版. Indeed, extracellular vesicles secreted by KLF2-transduced or shear-stress-stimulated HUVECs are enriched in miR-143/145 and control target gene expression in co-cultured SMCs. Extracellular vesicles derived from KLF2-expressing endothelial cells also reduced atherosclerotic lesion formation in the aorta of ApoE(-/-) mice. Combined, our results show that atheroprotective stimuli induce communication between endothelial cells and SMCs through an miRNA- and extracellular-vesicle-mediated mechanism and that this may comprise a promising strategy to combat atherosclerosis. .

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