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Review
. 2012 May;37(5):903-10.
doi: 10.1007/s11064-012-0708-2. Epub 2012 Feb 7.

Neuroinflammation and synaptic loss

Jagadeesh S Rao  1 , Matthew Kellom, Hyung-Wook Kim, Stanley I Rapoport, Edmund A Reese
Affiliations
Review

"VSports app下载" Neuroinflammation and synaptic loss

Jagadeesh S Rao et al. Neurochem Res. 2012 May.

Abstract

Neuroinflammation plays a critical role in the progression of many neurodegenerative, neuropsychiatric and viral diseases. In neuroinflammation, activated microglia and astrocytes release cytokines and chemokines as well as nitric oxide, which in turn activate many signal transduction pathways. The cytokines, interleukin-1 beta and tumor necrosis factor alpha, regulate transcription of a number of genes within the brain, which can lead to the formation of pro-inflammatory products of the arachidonic acid cascade VSports手机版. Formation of pro-inflammatory agents and associated cytotoxic products during neuroinflammation can be detrimental to neurons by altering synaptic proteins. Neuroinflammation as well as excitotoxic insults reduce synaptic markers such as synaptophysin and drebrin. Neurodegenerative, neuropsychiatric illnesses and viral infections are accompanied by loss of both pre- and post-synaptic proteins. These synaptic changes may contribute to the progressive cognitive decline and behavioral changes associated with these illnesses. .

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Conflict of interest statement (VSports在线直播)

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Figures (VSports)

Figure 1
Figure 1
Schematic representation of arachidonic acid cascade
Figure 2
Figure 2
Representation of cross-talk between neuroinflammation and excitotoxicity involving arachidonic acid cascade.
See this image and copyright information in PMC

"V体育官网" References

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