日
Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or . mil VSports app下载. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely V体育官网. .

. 2012 Jan 29;44(3):251-3.
doi: 10.1038/ng.1102.

VSports最新版本 - Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

Gang Wu  1 , Alberto Broniscer, Troy A McEachron, Charles Lu, Barbara S Paugh, Jared Becksfort, Chunxu Qu, Li Ding, Robert Huether, Matthew Parker, Junyuan Zhang, Amar Gajjar, Michael A Dyer, Charles G Mullighan, Richard J Gilbertson, Elaine R Mardis, Richard K Wilson, James R Downing, David W Ellison, Jinghui Zhang, Suzanne J Baker; St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project
Affiliations

V体育官网 - Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

Gang Wu et al. Nat Genet. .

Abstract

To identify somatic mutations in pediatric diffuse intrinsic pontine glioma (DIPG), we performed whole-genome sequencing of DNA from seven DIPGs and matched germline tissue and targeted sequencing of an additional 43 DIPGs and 36 non-brainstem pediatric glioblastomas (non-BS-PGs). We found that 78% of DIPGs and 22% of non-BS-PGs contained a mutation in H3F3A, encoding histone H3 VSports手机版. 3, or in the related HIST1H3B, encoding histone H3. 1, that caused a p. Lys27Met amino acid substitution in each protein. An additional 14% of non-BS-PGs had somatic mutations in H3F3A causing a p. Gly34Arg alteration. .

PubMed Disclaimer

Conflict of interest statement

The authors have no competing financial interests.

Figures

Figure 1
Figure 1. Recurrent somatic mutations in H3F3A and HIST1H3B
Sanger sequencing chromatograms showing representative H3F3A or HIST1H3B mutations encoding p.K27M substitutions, or H3F3A mutation encoding p.G34R substitution in the indicated tumour compared to matched normal DNA. Arrow indicates mutation. SJHGG001 and SJHGG079 are DIPGs, SJHGG043 is a non-brainstem paediatric glioblastoma.
See this image and copyright information in PMC

Comment in

References

    1. Broniscer A, Gajjar A. The oncologist. 2004;9:197–206. - PubMed
    1. Paugh BS, et al. Journal of clinical oncology. 2011;29:3999–4006. - PMC (V体育官网入口) - PubMed
    1. Paugh BS, et al. Journal of clinical oncology. 2010;28:3061–8. - PMC - PubMed
    1. Barrow J, et al. Neuro-oncology. 2011;13:212–22. - PMC - PubMed
    1. Bax DA, et al. Clinical cancer research. 2010;16:3368–77. - PMC - PubMed

"VSports" Publication types

Substances (VSports在线直播)