Objective: To investigate comprehensively the relationships between Behçet's disease (BD) clinical features and HLA-B51 or HLA-B5 (HLA-B51/B5) status using meta-analyses. VSports手机版.

Methods: Relevant publications were identified by a systematic literature search V体育安卓版. Eligible studies had to provide frequencies for one or more BD characteristics according to HLA-B51/B5 status. Pooled relative risks (RRs) were calculated by random-effects meta-analysis for those BD characteristics for which five or more relevant studies were identified. Between-study variability was assessed with I(2) and Q-statistics, and modelled using meta-regression. .

Results: Among the 859 publications evaluated, 72 (representing 74 study populations) met eligibility criteria. Pooled RRs (95% CIs) of the association of HLA-B51/B5 with the 14 analysed clinical characteristics were male sex 1. 14 (1. 05, 1. 23); eye involvement 1. 13 (1. 06, 1. 21); genital ulcers 1. 07 (1. 01, 1. 14); skin involvement 1. 10 (1. 03, 1. 16); erythema nodosum 1. 11 (0. 96, 1. 29); pseudofolliculitis 1. 07 (0. 93, 1. 23); positive pathergy test 1. 05 (0. 94, 1. 17); joint involvement 0. 94 (0. 86, 1. 04); neurological involvement 0. 95 (0. 71, 1. 27); gastrointestinal involvement 0. 70 (0. 52, 0. 94); thrombophlebitis 1. 17 (0. 77, 1. 76); vascular involvement 1. 00 (0. 68, 1. 47); chest involvement 1. 55 (0. 75, 3. 20) and orchiepididymitis 1. 13 (0. 59, 2 V体育ios版. 15). For most of the analysed outcomes, between-study heterogeneity was low or absent and most of the meta-regression models were statistically non-significant. .

Conclusion: The results of these meta-analyses showed that, in BD, HLA-B51/B5 carriage predominates in males and is associated with moderately higher prevalences of genital ulcers, ocular and skin manifestations, and a decreased prevalence of gastrointestinal involvement. VSports最新版本.