Background: Plasma human immunodeficiency virus type 1 (HIV-1) RNA suppression <50 copies/mL is regarded as the optimal outcome of highly active antiretroviral therapy (HAART). Current viral load (VL) assays show increased sensitivity, but the significance of RNA detection <50 copies/mL is unclear VSports手机版. .

Methods: This study investigated the virologic outcomes of 1247 patients with VL <50 copies/mL at an arbitrary time point during HAART (= T0), according to whether the actual, unreported (T0)VL was 40-49 copies/mL, RNA detected <40 copies/mL (RNA(+)), or RNA not detected (RNA(-)), as measured by the Abbott Real Time assay. Predictors of rebound >50 and >400 copies/mL over 12 months following T0 were analyzed with Cox proportional hazards models incorporating the (T0)VL and demographic and clinical data V体育安卓版. .

Results: Rebound rates >50 copies/mL were 34. 2% for (T0)VL 40-49 copies/mL, 11. 3% for RNA(+), and 4. 0% for RNA(-); rebound rates >400 copies/mL were 13. 0%, 3. 8%, and 1. 2%, respectively. The adjusted hazard ratios for rebound >50 copies/mL were 4. 67 (95% confidence interval, 2. 91-7. 47; P < . 0001) and 1. 97 (1. 25-3. 11; P < . 0001) with (T0)VL 40-49 copies/mL and RNA(+), respectively, relative to RNA(-), and 6. 91 (2. 90-16. 47; P < . 0001) and 2. 88 (1. 24-6. 69; P < . 0001), respectively, for rebound >400 copies/mL V体育ios版. The association was independent of adherence levels. .

Conclusions: In treated patients monitored by RealTime, a VL of 40-49 copies/mL and, to a lesser extent, RNA detection <40 copies/mL predict rebound >50 and >400 copies/mL independently of other recognized determinants. The goal of HAART may need to be revised to a lower cutoff than 50 copies/mL VSports最新版本. .