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Randomized Controlled Trial
. 2011 Oct;34(10):e158.
doi: 10.2337/dc11-1196.

Inhibition of IL-1beta improves fatigue in type 2 diabetes

Randomized Controlled Trial

Inhibition of IL-1beta improves fatigue in type 2 diabetes

Claudia Cavelti-Weder et al. Diabetes Care. 2011 Oct.
No abstract available

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References (V体育2025版)

    1. Cavadini G, Petrzilka S, Kohler P, et al. TNF-alpha suppresses the expression of clock genes by interfering with E-box-mediated transcription. Proc Natl Acad Sci USA 2007;104:12843–12848 - PMC - PubMed
    1. Larsen CM, Faulenbach M, Vaag A, et al. Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N Engl J Med 2007;356:1517–1526 - PubMed
    1. Rissanen A, Howard C, Botha J, Thuren T. IL-1β antibody (canakinumab) improves insulin secretion rates in subjects with impaired glucose tolerance (IGT) and type 2 diabetes (T2DM). Late breaking abstract presented at the 71st Scientific Sessions of the American Diabetes Association, 24–28 June 2011, San Diego Convention Center, San Diego, California.
    1. Donath MY, Weder C, Whitmore J, et al. XOMA 052, an anti-IL-1β antibody, in a double blind, placebo controlled, dose escalation study of the safety and pharmacokinetics in patients with type 2 diabetes mellitus – a new approach to therapy. Diabetologia 2008;51(Suppl. 1):A1
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