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. 2012 Mar;36(3):328-35.
doi: 10.1038/ijo.2011.159. Epub 2011 Aug 30.

Incidence and prevalence of copper deficiency following roux-en-y gastric bypass surgery

N Gletsu-Miller  1 , M Broderius, J K Frediani, V M Zhao, D P Griffith, S S Davis Jr, J F Sweeney, E Lin, J R Prohaska, T R Ziegler
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Incidence and prevalence of copper deficiency following roux-en-y gastric bypass surgery

"VSports在线直播" N Gletsu-Miller et al. Int J Obes (Lond). 2012 Mar.

Abstract

Introduction and objectives: The frequency of copper deficiency and clinical manifestations following roux-en-y gastric bypass (RYGB) surgery is not yet clear VSports手机版. Objectives were to determine the prevalence and incidence of copper deficiency in patients who have undergone RYGB. .

Design and methods: We sought to determine the number of RYGB patients undergoing medical and nutritional follow-up visits at the Emory Bariatric Center who experienced copper deficiency and associated hematological and neurological complaints (n=136). Separately, in patients followed longitudinally before and during 6 and 24 months following RYGB surgery, we obtained measures of copper status (n=16) V体育安卓版. Systemic blood cell counts and measures of copper, zinc and ceruloplasmin were determined using standardized assays in reference laboratories including atomic absorption spectrometry and immunoassays. .

Results: Thirteen patients were identified to have copper deficiency suggesting a prevalence of copper deficiency of 9. 6%, and the majority of these had concomitant complications including anemia, leukopenia and various neuro-muscular abnormalities. In the longitudinal study, plasma copper concentrations and ceruloplasmin activity decreased over 6 and 24 months following surgery, respectively (P<0. 05), but plasma zinc concentrations did not change. A simultaneous decrease in white blood cells was observed (P<0 V体育ios版. 05). The incidence of copper deficiency in these subjects was determined to be 18. 8%. .

Conclusions: The prevalence and incidence of copper deficiency following RYGB surgery was determined to be 9. 6% and 18. 8%, respectively, with many patients experiencing mild-to-moderate symptoms. Given that copper deficiency can lead to serious and irreversible complications if untreated, frequent monitoring of the copper status of RYGB patients is warranted. VSports最新版本.

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Conflict of interest statement

Conflict of interest

The authors declare no conflict of interest.

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Figure 1
Figure 1
Serum copper in a RYGB clinic population. Serum copper concentrations were determined in patients (n = 136) who had undergone RYGB surgery at the Emory Bariatric Center and had visited the clinic for medical and nutritional follow-up during March 2007 and March 2009. Each patient number and their copper measurement(s) is (are) plotted; some patients had multiple clinic visits. Closed squares are values in the normal range, (12.6–24.3 µmol l−1), 13 samples are below the normal cutoff and considered deficient (open squares).
Figure 2
Figure 2
Changes in plasma ceruloplasmin activity during 24 months following RYGB surgery. Ceruloplasmin activity was serially determined in study 2 subjects (n = 16) before (baseline), and 6 and 24 months following RYGB surgery and each individual data point is plotted (open squares). The mean and standard error of the mean for each timepoint is represented by closed squares. At 24 months following surgery, 3 ceruloplasmin activity values dropped below the normal cutoff. An asterisk (*) depicts values significantly different from baseline, P = 0.016.
Figure 3
Figure 3
Changes in ceruloplasmin activity and concentration following RYGB surgery. Changes in ceruloplasmin (Cp) density following surgery, relative to baseline levels, detected by western immunoblots in a subgroup of study 2 subjects who exhibited the greatest decrease in ceruloplasmin activity (mean = 44% of baseline) is shown (n = 5). Transferrin (Tf) density, used as a loading control, was not altered post surgery. Plasma copper (Cu) and zinc (Zn) concentrations were determined by flame atomic absorption spectrometry. An asterisk (*) depicts significant reductions compared with baseline measures, P<0.05.
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References

    1. Failla ML, Johnson MA, Prohaska JR. Copper. In: Bowman BA, Russell RM, editors. Present Knowledge in Nutrition. 8th ed. Washington, DC: ILSI Press; 2001. pp. 373–383.
    1. Andreini C, Banci L, Bertini I, Rosato A. Occurrence of copper proteins through the three domains of life: a bioinformatics approach. J Proteome Res. 2008;7:209–216. - PubMed
    1. Haremaki T, Fraser ST, Kuo YM, Baron MH, Weinstein DC. Vertebrate Ctr1 coordinates morphogenesis and progenitor cell fate and regulates embryonic stem cell differentiation. Proc Natl Acad Sci USA. 2007;104:12029–12034. - PMC - PubMed
    1. Matoba S, Kang JG, Patino WD, Wragg A, Boehm M, Gavrilova O, et al. p53 regulates mitochondrial respiration. Science. 2006;312:1650–1653. - PubMed
    1. White C, Lee J, Kambe T, Fritsche K, Petris MJ. A role for the ATP7A copper-transporting ATPase in macrophage bactericidal activity. J Biol Chem. 2009;284:33949–33956. - PMC - PubMed

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