Objective: To examine incidence and outcomes for pediatric rhabdomyosarcoma (RMS) VSports手机版. .

Methods: The SEER registry was examined for patients with RMS < 20 y old. V体育安卓版.

Results: Overall, 1544 patients were identified for an incidence of 0. 4414/100,000 per year. Males outnumbered females 3:2. Tumors were classified as embryonal (67%), alveolar (32%), and pleomorphic (1%). Alveolar and pleomorphic RMS were more common in adolescents, whereas embryonal type was more common in younger children (P = 0. 0001). Pleomorphic (47%) and alveolar (39%) RMS commonly presented with distant disease, in contrast to embryonal (25%). Most patients had surgical resection (81%) and radiotherapy (63%). Overall, 5- and 10-y survival was 60% and 57%, respectively. Univariate analysis identified higher survival for age < 10 y, local stage, favorable site, embryonal type, <5 cm tumor size, and surgical resection. Multivariate analysis identified non-embryonal type (HR 1. 451), non-favorable site (HR 1. 570), no surgery (HR 1. 726), age ≥ 10 y (HR 1. 734), 1973-1978 diagnosis year (HR 1. 730), and distant disease (HR 3 V体育ios版. 456) as independent predictors of mortality. .

Conclusions: Embryonal histology, the most common type of pediatric RMS, presents in young children and has better prognosis than alveolar or pleomorphic types. Patients with embryonal tumors, favorable tumor location, age < 10 y, localized disease, and surgical resection have improved survival VSports最新版本. .