<b draggable="FKzJGks"><bdo draggable="kLIHnU"></bdo></b><area dropzone="V0LdA9"></area> Skip to main page content (VSports app下载)
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official VSports app下载. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely V体育官网. .

Review
. 2011 Jul;22(7):259-65.
doi: 10.1016/j.tem.2011.03.005. Epub 2011 Apr 15.

Human resistin: found in translation from mouse to man

Daniel R Schwartz  1 , Mitchell A Lazar
Affiliations
Review

Human resistin: found in translation from mouse to man

"V体育官网" Daniel R Schwartz et al. Trends Endocrinol Metab. 2011 Jul.

Abstract

The discovery of resistin 10 years ago as a fat cell-secreted factor that modulates insulin resistance suggested a link to the current obesity-associated epidemics of diabetes and cardiovascular disease, which are major human health concerns VSports手机版. Although adipocyte-derived resistin is indisputably linked to insulin resistance in rodent models, the relevance of human resistin is complicated because human resistin is secreted by macrophages rather than adipocytes, and because of the descriptive nature of human epidemiology. In this review, we examine the recent and growing evidence that human resistin is an inflammatory biomarker and a potential mediator of diabetes and cardiovascular disease. .

PubMed Disclaimer

Figures (V体育官网入口)

Figure 1
Figure 1. Potential impact of resistin on human disease
Resistin is upregulated in response to genetic signals and various stimuli. As shown in studies of both human and animals, resistin may act on multiple cell types to promote inflammation, insulin resistance and cardiac pathology. Abbreviations: LPS, lipopolysaccharide; TNFα, tumor necrosis factor-alpha; IL-6, interleukin-6; IL-1β, interleukin-1beta; TZD, thiazolidinedione; PBMC, peripheral blood mononuclear cell; AMPK, adenosine monophosphate-activated protein kinase; SOCS-3, suppressor of cytokine signaling-3; NFkB, nuclear factor kappa B; VCAM-1, vascular cell adhesion molecule-1; ICAM-1, inter-cellular adhesion molecule-1; MCP-1, monocyte chemoattractant protein-1; ET-1, endothelin-1; MAPK, mitogen activated protein kinase.
See this image and copyright information in PMC

References

    1. Steppan CM, et al. The hormone resistin links obesity to diabetes. Nature. 2001;409:307–312. - PubMed
    1. Steppan CM, et al. A family of tissue-specific resistin-like molecules. Proc Natl Acad Sci U S A. 2001;98:502–506. - PMC - PubMed
    1. Kim KH, et al. A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation. J Biol Chem. 2001;276:11252–11256. - "VSports手机版" PubMed
    1. Rajala MW, et al. Cell type-specific expression and coregulation of murine resistin and resistin-like molecule-alpha in adipose tissue. Mol Endocrinol. 2002;16:1920–1930. - PubMed
    1. Rajala MW, et al. Regulation of resistin expression and circulating levels in obesity, diabetes, and fasting. Diabetes. 2004;53:1671–1679. - PubMed

MeSH terms