Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or . mil VSports app下载. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely V体育官网. .

. 2011 May;138(9):1827-38.
doi: 10.1242/dev.053645. Epub 2011 Mar 29.

VSports注册入口 - p53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition/delamination processes

Ariel Rinon  1 , Alina Molchadsky, Elisha Nathan, Gili Yovel, Varda Rotter, Rachel Sarig, Eldad Tzahor
Affiliations

p53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition/delamination processes

Ariel Rinon (VSports最新版本) et al. Development. 2011 May.

Abstract (VSports手机版)

Neural crest development involves epithelial-mesenchymal transition (EMT), during which epithelial cells are converted into individual migratory cells. Notably, the same signaling pathways regulate EMT function during both development and tumor metastasis. p53 plays multiple roles in the prevention of tumor development; however, its precise roles during embryogenesis are less clear. We have investigated the role of p53 in early cranial neural crest (CNC) development in chick and mouse embryos VSports手机版. In the mouse, p53 knockout embryos displayed broad craniofacial defects in skeletal, neuronal and muscle tissues. In the chick, p53 is expressed in CNC progenitors and its expression decreases with their delamination from the neural tube. Stabilization of p53 protein using a pharmacological inhibitor of its negative regulator, MDM2, resulted in reduced SNAIL2 (SLUG) and ETS1 expression, fewer migrating CNC cells and in craniofacial defects. By contrast, electroporation of a dominant-negative p53 construct increased PAX7(+) SOX9(+) CNC progenitors and EMT/delamination of CNC from the neural tube, although the migration of these cells to the periphery was impaired. Investigating the underlying molecular mechanisms revealed that p53 coordinates CNC cell growth and EMT/delamination processes by affecting cell cycle gene expression and proliferation at discrete developmental stages; disruption of these processes can lead to craniofacial defects. .

PubMed Disclaimer

Publication types

VSports手机版 - MeSH terms

LinkOut - more resources