Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or VSports app下载. mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. V体育官网.

. 2011 Feb 25;34(2):237-46.
doi: 10.1016/j.immuni.2011.01.016. Epub 2011 Feb 17.

Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria (VSports app下载)

Usriansyah Hadis  1 , Benjamin Wahl, Olga Schulz, Matthias Hardtke-Wolenski, Angela Schippers, Norbert Wagner, Werner Müller, Tim Sparwasser, Reinhold Förster, Oliver Pabst
Affiliations
Free article

"V体育ios版" Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria

"VSports手机版" Usriansyah Hadis et al. Immunity. .
Free article

Abstract (V体育2025版)

Tolerance to food antigen manifests in the absence and/or suppression of antigen-specific immune responses locally in the gut but also systemically, a phenomenon known as oral tolerance. Oral tolerance is thought to originate in the gut-draining lymph nodes, which support the generation of FoxP3(+) regulatory T (Treg) cells. Here we use several mouse models to show that Treg cells, after their generation in lymph nodes, need to home to the gut to undergo local expansion to install oral tolerance. Proliferation of Treg cells in the intestine and production of interleukin-10 by gut-resident macrophages was blunted in mice deficient in the chemokine (C-X3-C motif) receptor 1 (CX3CR1). We propose a model of stepwise oral tolerance induction comprising the generation of Treg cells in the gut-draining lymph nodes, followed by migration into the gut and subsequent expansion of Treg cells driven by intestinal macrophages. VSports手机版.

PubMed Disclaimer

VSports app下载 - Comment in

"V体育安卓版" Publication types

MeSH terms

LinkOut - more resources