Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site VSports app下载. .

Https

The site is secure V体育官网. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. .

. 2011 Oct;21(10):679-86.
doi: 10.1097/FPC.0b013e328343dd93.

"V体育官网" PharmGKB summary: methotrexate pathway

Torben S Mikkelsen  1 , Caroline F Thorn, Jun J Yang, Cornelia M Ulrich, Deborah French, Gianluigi Zaza, Henry M Dunnenberger, Sharon Marsh, Howard L McLeod, Kathy Giacomini, Mara L Becker, Roger Gaedigk, James Steven Leeder, Leo Kager, Mary V Relling, William Evans, Teri E Klein, Russ B Altman
Affiliations

"V体育2025版" PharmGKB summary: methotrexate pathway

"V体育2025版" Torben S Mikkelsen et al. Pharmacogenet Genomics. 2011 Oct.
No abstract available

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Stylized cell showing candidate genes involved in pharmacokinetics and pharmacodynamics of methotrexate. A fully interactive version is available online at http://www.pharmgkb.org/do/serve?objId=PA2039&objCls=Pathway, and includes additional views that show transport and action in different cell types.
See this image and copyright information in PMC

References

    1. Dervieux T, Wessels JA, Van der ST, Penrod N, Moore JH, Guchelaar HJ, et al. Gene–gene interactions in folate and adenosine biosynthesis pathways affect methotrexate efficacy and tolerability in rheumatoid arthritis. Pharmacogenet Genomics. 2009;19:935–944. - PubMed
    1. Pui CH, Campana D, Pei D, Bowman WP, Sandlund JT, Kaste SC, et al. Treating childhood acute lymphoblastic leukemia without cranial irradiation. N Engl J Med. 2009;360:2730–2741. - V体育官网 - PMC - PubMed
    1. Widemann BC, Balis FM, Kempf-Bielack B, Bielack S, Pratt CB, Ferrari S, et al. High-dose methotrexate-induced nephrotoxicity in patients with osteosarcoma. Cancer. 2004;100:2222–2232. - PubMed
    1. Trevino LR, Shimasaki N, Yang W, Panetta JC, Cheng C, Pei D, et al. Germ line genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects. J Clin Oncol. 2009;27:5972–5978. - PMC (VSports最新版本) - PubMed
    1. Buitenkamp TD, Mathot RAA, de Haas V, Pieters R, Zwaan CM. Methotrexate-induced side effects are not due to differences in pharmacokinetics in children with Down syndrome and acute lymphoblastic leukemia. Haematologica. 2010;95:1106–1113. - PMC (VSports) - PubMed

Publication types

MeSH terms (V体育平台登录)

LinkOut - more resources