Heading in a new direction: drug permeability in breast cancer brain metastasis
- PMID: 21045085
- DOI: 10.1158/1078-0432.CCR-10-2502
"V体育ios版" Heading in a new direction: drug permeability in breast cancer brain metastasis
Abstract
Systemic therapies for breast cancer brain metastasis are largely unsuccessful. Mouse models of brain metastasis show significant heterogeneity in uptake of paclitaxel and doxorubicin, with average levels more than those seen in normal brain tissue, but significantly less than in metastases to other organs VSports手机版. .
©2010 AACR.
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Heterogeneous blood-tumor barrier permeability determines drug efficacy in experimental brain metastases of breast cancer.Clin Cancer Res. 2010 Dec 1;16(23):5664-78. doi: 10.1158/1078-0432.CCR-10-1564. Epub 2010 Sep 9. Clin Cancer Res. 2010. PMID: 20829328 Free PMC article.
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