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. 1990 Dec;31(12):1365-70.
doi: 10.1136/gut.31.12.1365.

Differential expression of CD25 (interleukin-2 receptor) on lamina propria T cells and macrophages in the intestinal lesions in Crohn's disease and ulcerative colitis

M Y Choy  1 , J A Walker-Smith, C B Williams, T T MacDonald
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Differential expression of CD25 (interleukin-2 receptor) on lamina propria T cells and macrophages in the intestinal lesions in Crohn's disease and ulcerative colitis

M Y Choy et al. Gut. 1990 Dec.

Abstract

Many interleukin-2 receptor (CD25) bearing cells can be identified by alkaline phosphatase immunohistochemistry in the diseased intestinal lamina propria of children with Crohn's disease or ulcerative colitis, but rarely in normal intestine. In both diseases, the CD25+ cells are present as aggregates in the lamina propria below the epithelium, and constitute a large proportion of the lamina propria mononuclear cells. In Crohn's disease, but not ulcerative colitis, CD25+ cells are abundant in the submucosa. The CD25+ cells in Crohn's disease are 58-88% CD3+, CD4+, CD8-, indicating that they are T cells, whereas in ulcerative colitis the CD25+ cells are greater than 80% CD3-, CD4+, HLA-DR+, indicating that they are macrophages. Thus, differential expression of CD25 on T cells and macrophages serves to distinguish the immunologic lesions in ulcerative colitis and Crohn's disease. VSports手机版.

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Comment in

  • Interleukin-2 receptor expression.
    Mahida YR. Mahida YR. Gut. 1991 Apr;32(4):456-7. doi: 10.1136/gut.32.4.456-a. Gut. 1991. PMID: 2026348 Free PMC article. No abstract available.

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